Gastric Cancer Clinical Trial
Official title:
A Comparison Between D1 and D2 Lymphadenectomy in Gastric Cancer : A Prospective Randomized Controlled Trial
Gastric cancer remains the second most common cancer worldwide.Although the prognosis is
poor for majority of patients , long term survival is achievable in patients in whom
surgical resection is possible.
However the results of surgery are generally disapointing in most large series.The exception
to this appears to be Japan and far east where a standardized approach to surgery is
undertaken with low morbidity and mortality.The extent of surgery and particularly the
development of systematic lymphadenectomy(D2)has been credited in Japan for the improved
outcome in patients with gastric cancer.
Hence for comparing the difference between D1 and D2 lymphadenectomy for gastric cancer in
terms of overall survival,disease free survival and loco regional recurrence and also post
operative morbidity and mortality following both these procedures,this study has been
undertaken.
In D1 lymphadenectomy, only those lymph nodes which are adjacent to the part of stomach
being resected will be removed.In D2 lymphadenectomy other lymph nodes draining the stomach
will also be removed according to internationally accepted guidelines and also include
resection of greater omentum along with anterior layer of transverse mesocolon and lesser
omentum upto its attachment to hepatoduodenal ligament.
Currently both these procedures are widely practised worldwide and there is no definite
evidence showing the superiority of one procedure over the other.Neither is any of these
procedures experimental.
We are doing this trial to see whether one of these procedures is superior to the other.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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