Gastric Cancer Clinical Trial
Official title:
A Multicenter, Open-Label, Two-Stage, Phase II Study Of PS-341 (LDP-341, NSC # 681239) In Patients With Unresectable Or Metastatic Gastric Adenocarcinoma
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary
for their growth.
PURPOSE: Phase II trial to study the effectiveness of bortezomib in treating patients who
have unresectable or metastatic gastric cancer or gastroesophageal junction adenocarcinoma.
OBJECTIVES:
Primary
- Determine the efficacy of bortezomib in patients with unresectable or metastatic
gastric or gastroesophageal junction adenocarcinoma.
Secondary
- Determine the toxicity of this drug in these patients.
- Determine possible predictors of response to this drug, using pretreatment tumor
immunohistochemistry, in these patients.
OUTLINE: This is an open-label, nonrandomized, multicenter study.
Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Courses repeat
every 3 weeks in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 1 year.
PROJECTED ACCRUAL: A total of 15-33 patients will be accrued for this study within 5-12
months.
;
Masking: Open Label, Primary Purpose: Treatment
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