Effect of Meal Number, Frequency, and Form on Satiety and Metabolism After Weight Loss Surgery

Obesity Clinical Trial

Official title: Effect of Meal Number, Frequency, and Form on Satiety and Metabolism After Weight Loss Surgery

Status Completed

Clinical Trial Summary

Analyze the effect of meal pattern (meal number, frequency, and form) on satiety, gut peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric bypass surgery (GBP).

Clinical Trial Description

The main goal is to study the effect of meal number, size and texture on metabolism and incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a single meal will be served, on the second study day, three small isocaloric meals, with the order of the conditions randomly assigned. The total amount of calories and the overall nutrient composition will be equivalent between conditions. The meals will be either all solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or liquid test meals.

Gastric emptying will be measured by the acetaminophen test. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Gastric Bypass Surgery
• Obesity
• Weight Loss

• NCT number: NCT01938469
• Study type: Interventional
• Source: St. Luke's-Roosevelt Hospital Center
• Status: Completed
• Phase: N/A
• Start date: September 2010
• Completion date: July 2014