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Clinical Trial Summary

The aim of this project is to investigate the presence of bacteria in the gallbladder wall and the bile in patients undergoing cholecystectomy, to determine if the standard empirical antibiotic treatment used currently is effective against the most common pathogens.


Clinical Trial Description

The investigators will compare two groups of patients; patients with acute calculous cholecystitis undergoing acute laparoscopic cholecystectomy and patients without cholecystitis undergoing elective laparoscopic cholecystectomy. Secondly, the investigators wish to investigate if the presence of bacteria correlates with the grade of inflammation, and whether this can predict when cholecystitis is caused by infection. In a clinical setting, this can provide important knowledge regarding the choice of antibiotics currently used to treat and prevent infection in the gallbladder. The investigators will conduct two studies, one investigating the bacteria in bile and in the gallbladder wall and the resistens of the bacteria to antibiotics and another study investigating the histopathology of the gallbladder wall to see if the bacteria present is the cause of inflammation or an actual infection. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05712733
Study type Observational [Patient Registry]
Source Organkirurgisk afdeling, sygehus lillebælt, Kolding
Contact Malene B Dissing, MD
Phone 004528745840
Email malene.borgager@rsyd.dk
Status Recruiting
Phase
Start date April 1, 2023
Completion date October 2025

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