Frailty Clinical Trial
Official title:
Prevalence of Frailty in Patients With a Cardiovascular Disease and Correlations With Markers of Exercise
In the first part of this study the prevalence of frailty in patients with cardiovascular
disease will be examined. Frailty is defined as a progressive age-related decline in
physiological systems that results in decreased reserves of intrinsic capacity, which confers
extreme vulnerability to stressors. Patients (≥65 years, men and women) suffering from heart
failure or undergoing a coronary artery bypass grafing (CABG) or percutaneous coronary
intervention (PCI) will be included. Based on the phenotype of Fried, frailty will be
examined in the physical domain. Moreover, the nutritional, social, psychological and
cognitive domain of frailty will be examined. This will result in a total score of 0 (no
frailty) to 24 (severe frailty), divided into four categories: no frailty (score 0-6), minor
frailty (score 7-12), moderate frailty (score 13-18) or severe frailty (score 18-24).
Besides this frailty protocol, a few other measurements will be completed to collect
additional information about the functioning of the patient.
At discharge from the hospital, some of these patients will start with a cardiac
rehabilitation program. To define the exercise intensity of this program, patients will
perform a maximal exercise test (CPET). In the second part of this study, correlations will
be examined between markers of frailty and markers of exercise from the CPET (e.g. maximal
heart rate, maximal oxygen uptake).
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