Healthy Clinical Trial
Official title:
Aromatase Activity and Ovarian Growth Factors in Preovulatory Follicles
The purpose of the study is to understand how the ovarian follicle (the fluid filled
structure in the ovary that contains the egg) makes estrogen and other hormones during
normal aging, in women with different ethnic backgrounds, and in Fragile X premutation
carriers.
During reproductive aging, estradiol levels are increased, a phenomenon that may be related
to increased aromatase activity. The investigators' own preliminary data suggest that
estradiol is increased in African-American women compared to Caucasian women, which may also
be related to aromatase activity. In addition, the investigators have examined female
fragile X premutation carriers who still have regular menstrual cycles and have demonstrated
evidence of early ovarian aging compared to age-matched controls.
**WE ARE RECRUITING ONLY WOMEN WITH FRAGILE-X PREMUTATION**
The purpose of the study is to examine intrafollicular changes in aromatase and ovarian
growth factors in reproductive aged women,African-American women compared to Caucasian
controls, and Fragile X premutation carriers.
Hypotheses:
- Aromatase activity is up-regulated in preovulatory follicles with aging, accounting for
the increased estradiol levels in the face of decreased inhibin secretion in
reproductive aging.
- Increased estradiol in the face of normal inhibin A and inhibin B suggests
up-regulation of aromatase in African-American women.
- Aromatase activity is down-regulated in preovulatory follicles in fragile X premutation
carriers compared to age-matched controls and the activity is associated with FMR1 mRNA
levels.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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