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Fractures, Ununited clinical trials

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NCT ID: NCT03701269 Recruiting - Orthopedic Clinical Trials

Long-term Surgical Outcomes of Scaphoid Proximal Pole Fracture Nonunion

Start date: August 14, 2018
Phase:
Study type: Observational

The treatment for scaphoid proximal pole nonunion remains challenging due to the poor vascularity in the proximal pole fragment, associated SL injury and the technique of fixation. Vascularized bone grafts and non-vascularized iliac bone graft have been used in patients with scaphoid proximal pole nonunion, but the indication has not been well clarified. Alternatively, we have been treating such patients with vascularized bone graft , or non-vascularized bone graft with screw or k-wire fixation with considerable success. The purpose of this study is to evaluate and analyze retrospectively the surgical efficacy of our procedure.

NCT ID: NCT03415958 Completed - Clinical trials for Malunion of Fracture of Clavicle

A Prospective Cohort of Displaced Adolescent Midshaft Clavicle Fractures

Start date: March 28, 2012
Phase: N/A
Study type: Observational

Outcomes for displaced midshaft clavicle fractures in adolescents are not defined. The current method of treatment for these fractures is non-operative management. There is recent Level 1 evidence in the adult literature to suggest that outcomes are superior when these fractures are managed surgically with open reduction and internal fixation.

NCT ID: NCT03382483 Enrolling by invitation - Clinical trials for Mitigation of Fracture Non-union in Patients at Risk

Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk

BONES
Start date: October 16, 2017
Phase:
Study type: Observational

This study is one of three separate studies of the Bioventus Observational Non-interventional EXOGEN Studies (BONES) program. Eligibility for each study is determined by fractured bone.

NCT ID: NCT03325504 Active, not recruiting - Non Union Fracture Clinical Trials

A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union

ORTHOUNION
Start date: September 5, 2017
Phase: Phase 3
Study type: Interventional

ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.

NCT ID: NCT03266874 Active, not recruiting - Clinical trials for Rheumatoid Arthritis

G7 BiSpherical Acetabular Shell PMCF Study

Start date: December 10, 2017
Phase:
Study type: Observational

The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.

NCT ID: NCT03129971 Active, not recruiting - Clinical trials for Nonunion of Fracture

Platelet-rich Plasma Combined With Conventional Surgery in the Treatment of Atrophic Nonunion of Femoral Shaft Fractures

Start date: August 2014
Phase: N/A
Study type: Interventional

To objectively analyze the effectiveness of platelet-rich plasma (PRP) combined with conventional surgery in the treatment of atrophic nonunion of femoral shaft fractures.

NCT ID: NCT03031509 Not yet recruiting - Nonunion Fracture Clinical Trials

Treatment of Nonunion of Limb Fracture With Human Amniotic Epithelial Cells(hAECs)

Start date: December 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of human amniotic epithelial cells transplant in nonunion of limb fracture patients.

NCT ID: NCT02383160 Active, not recruiting - Fractures, Ununited Clinical Trials

Scaphoid Non-union and Low-intensity Pulsed Ultrasound Trial

SNAPU
Start date: September 2014
Phase: N/A
Study type: Interventional

This is a prospective, double-blind, multicentered, randomized controlled trial to determine the effectiveness of low-intensity pulsed ultrasound in decreasing the time to union of scaphoid non-unions after operative fixation as measured by serial CT scanning. Multiple centers across Canada will be involved in the study. Blinding will include patients, surgeons, research assistants, as well as all data handlers and analysts until trial completion or mid-term analysis.

NCT ID: NCT02307435 Recruiting - Non Union Fracture Clinical Trials

Allogenic Mesenchymal Stem Cell for Bone Defect or Non Union Fracture

AMSC
Start date: August 2014
Phase: Phase 0
Study type: Interventional

Mesenchymal stem cell (MSC) is one kind of stem cell which is gained form adult tissue. Although MSC derived from autogenic bone marrow are proven to help regeneration in non union fracture and long bone defect, the aspiration process through iliac crest is invasive and painful. Therefore, alternative source of MSC which is less invasive is needed. Adipose and umbilical cord is a "waste product" that proven to contain enormous MSC. Furthermore adipose and umbilical cord as an allogenic source is more abundant in number compares to autogenic bone marrow. This enormous source need and adequate preservation technique before applied to the patient. According to that, researchers want to explore the potency of MSC from bone marrow, umbilical cord and adipose as the source of allogenic MSC and the effect of cryopreservation technique to the viability and quality of MSC. We will also compare the effectivity of MSC implantation from bone marrow, umbilical cord and adipose applied to non union fracture and long bone defect. Samples from bone marrow, umbilical cord and adipose are cultured and the viability of the cells are observed. Some of the cells are implanted directly to the patient with non union fractures and long bone defect while some are cryopreserved in liquid nitrogen -190 degree Celsius in three months. All samples are thawed and the viability of the cells are observed. Patient who are implanted by MSC allogenic will undergo clinical and radiological examination in the third, sixth and twenty second month after implantation.

NCT ID: NCT02230514 Completed - Clinical trials for Atrophic Nonunion of Fracture

Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones

Start date: November 20, 2014
Phase: Phase 1/Phase 2
Study type: Interventional

The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest. XCEL-MT-OSTEO-ALPHA is a tissue engineering product composed by "ex-vivo" expanded autologous mesenchymal stromal cells fixed in allogenic bone tissue, produced by Xcelia (Blood and Tissue Bank of Catalonia). The working hypothesis proposes that the tissue engineering is a valid and useful technique to achieve bone regeneration up to consolidation of non-union fractures.