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Food-drug Interaction clinical trials

View clinical trials related to Food-drug Interaction.

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NCT ID: NCT03948243 Completed - Clinical trials for Food-drug Interaction

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

Start date: April 1, 2019
Phase: Phase 1
Study type: Interventional

Human safety studies will be carried out to test whether red clover botanical dietary supplements used by peri- and post-menopausal women are safe to use with Food and Drug Administration (FDA)-approved drugs. To test this, a red clover dietary supplement (previously tested in women at the University of Illinois at Chicago without any harmful effects) will be given with four selected FDA-approved drugs to determine if the Licorice supplement can increase or decrease how these medications are absorbed, metabolized and excreted by the human body. Preclinical studies predict that the licorice supplement might affect the metabolism or break down of these probe drugs.

NCT ID: NCT03442621 Completed - Healthy Clinical Trials

Relacorilant Food Effect Study in Healthy Subjects

Start date: January 16, 2018
Phase: Phase 1
Study type: Interventional

This is an open-label, randomized, single-dose, 3-period crossover, Williams' design, food-interaction (fasted and fed arms) study conducted in healthy subjects.

NCT ID: NCT03215875 Completed - Clinical trials for Food-drug Interaction

A Food Effect Study of 60mg ER Torsemide

Start date: October 17, 2017
Phase: Phase 1
Study type: Interventional

This study will evaluate the effects of a high-fat meal (food effect) on the bioavailability and pharmacokinetics of 60mg ER Torsemide tablet after single dose oral administration in healthy volunteers. The study will be conducted as a two-sequence to period crossover study to compare 60mg ER Torsemide ER bioavailability under fed and fasting conditions. 60mg ER torsemide is a new strength and dosage form.

NCT ID: NCT03205787 Completed - Clinical trials for Food-drug Interaction

Red Clover Botanical Dietary Supplements - Metabolism and Safety in Women

Start date: September 21, 2017
Phase: N/A
Study type: Interventional

Human safety studies were carried out to test whether red clover botanical dietary supplements used by peri- and post-menopausal women are safe to use with Food and Drug Administration (FDA)-approved drugs. To test this, a red clover dietary supplement (previously tested in women at the University of Illinois at Chicago without any harmful effects) was given with four selected FDA-approved drugs to determine if the red clover supplement can increase or decrease how these medications are absorbed, metabolized and excreted by the human body. Preclinical studies predicted that the red clover supplement might affect the metabolism or break down of these probe drugs.

NCT ID: NCT01526213 Completed - Clinical trials for Food-drug Interaction

Do Furanocoumarins Mediate the Fexofenadine-grapefruit Juice Interaction?

Start date: September 2009
Phase: N/A
Study type: Interventional

Purpose: Grapefruit juice is one of the most extensively studied dietary/natural substances shown to interact with a variety of medications. However, unanswered questions remain regarding the causative ingredients and mechanisms underlying such drug-grapefruit juice interactions. Compounds in grapefruit juice called furanocoumarins have been established as major causative ingredients, which act by inhibiting the elimination (metabolism) of drugs, leading to increased circulating drug concentrations. Increased drug concentrations can in turn lead to increased drug potency or even toxicity. Grapefruit juice also has been shown, paradoxically, to decrease circulating concentrations of some drugs, including the non-sedating antihistamine agent, fexofenadine (Allegra), which undergoes negligible metabolism. Whether or not furanocoumarins mediate the decrease in fexofenadine concentrations is unknown. The purpose of the proposed study is to compare the effects of a "furanocoumarin-free" grapefruit juice with grapefruit juice on circulating concentrations of fexofenadine.