Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose Clinical Trial
Official title:
Lactose: A Unique Carbohydrate Enabling Homeostatic Regulation of Blood Glucose & Insulin
Lactose, one of the key nutrients in human milk may be critically important to infants for
more reasons than being a source of energy. We are interested in understanding how lactose
when compared to other sugars influences how nutrients, specifically macronutrients are
handled after digestion and absorption. To date, there have been no studies looking at how
fat and protein varies when lactose compared to other sugars is ingested. There may be
metabolic advantages to considering lactose for nutrition support of premature infants
rather than glucose or dextrose as is often used in intravenous feeds, or the corn syrup
solids in lactose-free formulas. We hope the information from this study will provide new
information on the unique aspects of lactose.
Hypothesis: The hypothesis is that providing carbohydrate as lactose:
1. minimizes the amount of carbohydrate that is converted into fat
2. enables a relatively constant metabolic state throughout feeding interval that avoids
swings of high to low insulin, glucose, and fats.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor)