Focal Drug-resistant Epilepsy Clinical Trial
Official title:
Multimodal Study of the Human Brain Epilepsy Tissue
The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy. The aim of the study will be to identify new pathophysiological pathways. For this purpose, the investigators will investigate with a multimodal approach blood and brain samples from patients undergoing a surgery for focal drug-resistant epilepsy. The adult patients will be enrolled either during the pre-surgical evaluation or right before the surgery.
This study aims to investigate blood and brain samples from patients with drug-resistant epilepsy in order to identify new pathophysiological biomarkers. The investigators will first conduct multimodal research, including: - electrophysiological analyses - immunohistochemistry and genetic studies - biochemistry analyses Samples will be stored at -80°C for future research. Patients will undergo a follow-up evaluation within the 36 months following the surgery. New clinical data and biological samples will be collected then. ;