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Fluorescence clinical trials

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NCT ID: NCT06235125 Not yet recruiting - Osteosarcoma Clinical Trials

Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

Cytalux
Start date: January 20, 2024
Phase: Phase 1
Study type: Interventional

Pediatric subjects aged 6-17 with biopsy confirmed cancer and imaging findings suspicious for pulmonary metastatic disease scheduled to undergo pulmonary metastasectomy via and open or minimally invasive approach.

NCT ID: NCT06129669 Enrolling by invitation - Surgery Clinical Trials

ICG Indocyanine Green in Reconstructive Surgery

ICG-R
Start date: May 9, 2023
Phase:
Study type: Observational

The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative technique to quantify tissue perfusion. Based on the results obtained in other subspecialties, NIR fluorescence appears to be a promising way to quantify tissue perfusion in reconstructive surgery. Fluorescence research has previously been used in the context of microsurgery and breast reconstructions using implants, but structural objective determinations are lacking. Our study is successful if we are able to determine a cut off value for the absolute or relative perfusion parameters.

NCT ID: NCT06033794 Recruiting - Indocyanine Green Clinical Trials

Applications of Fluorescence Imaging Guided Lymph Node Dissection and Fluorescence Angiography of Inferior Mesenteric Artery Assisted Left Colic Artery Preservation

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

To investigate the accuracy of fluorescence angiography technique IMA classification and the impact of lymph node mapping technique on the dissection of No. 253 lymph nodes.

NCT ID: NCT05730595 Not yet recruiting - Clinical trials for Colorectal Neoplasms

Fluorescence Laparoscopic Navigation for Rectal Cancer and Sigmoid Colon Cancer

FLORA-01
Start date: September 1, 2023
Phase: N/A
Study type: Interventional

To explore the short-term and long-term outcomes of fluorescence laparoscopic navigation D2 lymph node dissection for colorectal cancer surgery by comparing it with D3 lymph node dissection.

NCT ID: NCT05498051 Completed - Clinical trials for Colorectal Neoplasms

Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.

IBIZA-1
Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using peritumoral submucosal injections

NCT ID: NCT05497726 Completed - Clinical trials for Colorectal Neoplasms

Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Intravenous Bevacizumab-800CW

IBIZA-2
Start date: January 27, 2023
Phase: N/A
Study type: Interventional

This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using intravenous administration.

NCT ID: NCT05227950 Recruiting - Biomarkers Clinical Trials

Cell-free DNA Quantification for Predictive Marker of Palliative Chemotherapy

Start date: January 1, 2022
Phase:
Study type: Observational [Patient Registry]

This study is design to address, as follows: 1. correlation between fluorescence-based CFD measurements and tumor burden (primary tumor size, number of metastatic sites) 2. fluorescence-based CFD measurements and changes are related to tumor response. Based on the results of this study, the role of fluorescence-based CFD as a predictive biomarker for palliative chemotherapy is to be confirmed.

NCT ID: NCT03757507 Not yet recruiting - Atherosclerosis Clinical Trials

Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT

Carotid
Start date: April 10, 2019
Phase: N/A
Study type: Interventional

Determining whether we could visualize uptake of the fluorescent tracer Bevacizumab-800CW, targeting VEGF-A in atherosclerotic plaques by using the new imaging technique Multispectral Optoacoustic Tomography both in- and ex vivo.