Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients

Postoperative Complications Clinical Trial

Official title: The Effects on Fluid Balance and Renal Function Using a Restrictive Fluid Strategy in the Postoperative Setting in Patients With Low Urinary Output Undergoing Pancreatic Surgery

Status Terminated

Clinical Trial Summary

Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics. However, overloading patients with fluid also have several risks and known complications. Studies have also shown that a short period of decreased urinary output in the postoperative period do not have an increased incidence of acute renal failure. The aim of our study is to investigate the difference in renal function and postoperative complications associated with fluid overload on these patients that are randomized to either receiving a fluid bolus directly when urinary output decreases or to await for a maximum of four hours to see if urinary output increases spontaneously.

Clinical Trial Description

Patents after pancreatic surgery will be included in the study. Oliguric patients (urine output <0.5 ml/kg/h) will be randomized to fluid bolus (5ml/kg Ringer's Acetate in 30 minutes) or no intervention. Primary outcome is difference in urine output two hours after the fluid bolus or no intervention. ;

Related Conditions & MeSH terms

• Fluid Overload
• Fluid Therapy
• Pancreas Disease
• Pancreatic Diseases
• Postoperative Complications
• Postoperative Period

• NCT number: NCT03553394
• Study type: Interventional
• Source: Uppsala University
• Status: Terminated
• Phase: N/A
• Start date: October 1, 2018
• Completion date: August 30, 2022