The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure

Status Completed

Clinical Trial Summary

use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain. injection of platelet rich plasma under fissure base and edges had the advantage of improved fissure healing and reduction of the pain, with minimal side effects.

Clinical Trial Description

Thirty milliliters of venous blood were withdrawn into eight syringes with preloaded 0.4 milliliters of anticoagulant (dextrose solution A) in each syringe to achieve concentration of 9:1. The mixture centrifuged for 3000 round per minute for three minutes. After centrifugation separation of supernatant from the red blood cells, using three way-stopcock connector to collect the supernatant of all syringes into four new syringes that preloaded with 1 microgram of Prostaglandin E1 that diluted in normal saline (0.05 milliliters). The four syringes centrifuge at 4000 round per minute for 15 minutes. The supernatant discarded using a three way-stopcock connector. The sediment mixed with vortex mixer (Vortex V-1 plus, BIOSAN). ;

Study Design

Related Conditions & MeSH terms

Fissure in Ano

Clinical Trial Details

NCT number	NCT05837403
Study type	Interventional
Source	Al-Kindy College of Medicine
Contact
Status	Completed
Phase	Phase 3
Start date	October 1, 2020
Completion date	September 30, 2022

View Details

See also
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