Field Cancerization for Cannabis Smokers Clinical Trial
Official title:
Detection of Field Cancerization in the Clinically Normal Oral Mucosa of Cannabis and Cigarette Smokers (Ex-vivo Study)
The aim of this study is to detect P53 expression in clinically normal oral mucosa of cigarette smokers, simultaneous cigarette and cannabis smokers and non-smokers as a surrogate marker for field cancerization.
Roles and Responsibilities:
1. Ali Abd El Wahed Abd El Fatah Kotb (A.K.) operator, data enterer, Assistant lecturer,
Oral and Maxillofacial Pathology, Faculty of Oral and Dental Medicine, Cairo university,
Egypt.
2. Professor Dr. Heba Dahmoush (H.D.) main supervisor, data monitoring,auditing professor,
Oral and Maxillofacial Pathology, Faculty of Oral and Dental Medicine, Cairo university,
Egypt.
3. Eman Desoky (E.D.) sample size calculation, statistician,Faculty of Oral and Dental
Medicine, Cairo University, Egypt.
4. Evidence Based Dentistry Committee (CEBD)help in reporting study protocol following
SPIRIT guidelines,Faculty of Oral and Dental Medicine, Cairo University, Egypt.
5. Research Ethics Comittee (CREC)protocol reviewer in order to protect the right, safety,
dignity and well-being of the participants, Faculty of Oral and Dental Medicine, Cairo
University, Egypt.
1- Intervention: A.K. will collect specimens from cigarette smokers and simultaneous
cigarette and cannabis smokers. then the expression of p53 as a marker for field
cancerization will be investigated in formaline fixed paraffine embedded specimens of mucosal
biopsies obtained from the oral mucosa of both groups.
2-comparator: mucosal biopsies from non smokers will be investigated as a copmaratitive to
smokers group.
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