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Fibromyalgia clinical trials

View clinical trials related to Fibromyalgia.

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NCT ID: NCT01172795 Recruiting - Chronic Pain Clinical Trials

Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain

Start date: July 2010
Phase: N/A
Study type: Observational

Diffuse noxious inhibitory control In order to quantify central sensitization in chronic pain patients, the Diffuse Noxious Inhibitory Control (DNIC) model has been used frequently. DNIC relies on painful conditioning stimulation of one part of the body to inhibit pain in another part, to remove the "noise" and to focus on relevant stimuli. Earlier studies provided evidence for malfunctioning of DNIC in Fibromyalgia (FM) patients. However, the cause of this impairment is not yet elucidated, and further study is required to unravel the pathophysiology of DNIC in FM. Hypothalamus-Pituitary-Adrenal (HPA) axis Besides neural mechanisms, also hormonal abnormalities could cause altered pain processing. Cortisol is released in answer to pain to suppress the pain. Given the evidence for hypofunction of the hypothalamic-pituitary-adrenal axis and the lower cortisol release in response to stressors in a proportion of FM patients and in chronic whiplash associated disorders (WAD) patients, the relation between pain and cortisol in these patients may be an interesting topic to consider. Neurocognitive performance Besides chronic pain, people with chronic WAD and FM suffer from severe concentration difficulties and decreased neurocognitive capabilities (reduced reaction time, short term memory deficits etc. The decreased neurocognitive performance is known to be related to pain severity in various chronic pain populations. It is hypothesized that malfunctioning of descending inhibitory pathways and subsequent chronic pain experience precludes optimal neurocognitive performance. Objectives The present investigation addresses the (patho)physiological mechanisms of DNIC in chronic pain populations. 1. Firstly, patients with FM, chronic WAD and healthy controls are compared regarding functioning of DNIC, cortisol levels and response and neurocognitive performance (case-control). 2. Secondly, the possible interaction between the functioning of DNIC, cortisol and neurocognitive performance is studied in patients with FM, WAD and healthy control subjects (cross-sectional). 3. Thirdly, to examine whether a fatiguing neurocognitive stressor changes DNIC and cortisol levels in patients with FM, chronic WAD or healthy sedentary control subjects.

NCT ID: NCT01151163 Recruiting - Fibromyalgia Clinical Trials

Peripheral Arterial Tonometry (PAT) Evaluation of Sleep in Fibromyalgia

Start date: January 2011
Phase: N/A
Study type: Observational

Fibromyalgia syndrome (FMS) is characterized by the presence of widespread pain, chronic fatigue and typical sleep disturbances. The purpose of the current study is to investigate the nature of sleep disturbance in FMS, using a novel technology. Peripheral arterial tonometry is a method by which peripheral arterial tone is measured non - invasively using in an ambulatory setup during sleep. The information collected reflects autonomic nervous system function and respiratory changes during sleep. We intend to utilize this technique in order to improve our understanding of the interrupted patterns of sleep in FMS and as a possible biomarker which may be used in the future to follow up FMS patients and their response to treatment.

NCT ID: NCT01149018 Recruiting - Fibromyalgia Clinical Trials

Efficacy Trial of Oral Tetrahydrocannabinol in Patients With Fibromyalgia

Start date: June 2010
Phase: N/A
Study type: Interventional

The objective of the study is to evaluate the effectiveness of oral tetrahydrocannabinol in patients suffering from Fibromyalgia

NCT ID: NCT01026077 Recruiting - Fibromyalgia Clinical Trials

The Savella Pregnancy Registry

SPR
Start date: November 2009
Phase:
Study type: Observational [Patient Registry]

The Savella Pregnancy Registry is a US based registry designed to monitor pregnancies exposed to Savella (milnacipran HCI). This is an observational, exposure-registration and follow-up registry designed primarily to estimate the prevalence of major congenital anomalies, and secondarily to estimate the prevalence of recognized spontaneous abortions, stillbirths, induced abortions, minor congenital anomalies, and any serious adverse pregnancy outcomes among pregnancies exposed to Savella as well as adverse outcomes observed during the first year of life in off-springs born from these exposed pregnancies. Live offspring are followed from birth until age one. The Savella Pregnancy Registry is sponsored by AbbVie (formerly Actavis PLC, Forest Laboratories Inc., and Allergan) and managed by Syneos Health.

NCT ID: NCT00947622 Recruiting - Fibromyalgia Clinical Trials

Occipital Transcranial Direct Current Stimulation in Fibromyalgia

Start date: July 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is to investigate whether transcranial direct current stimulation is effective in the treatment of fibromyalgia related pain. The study provides a placebo arm and the design is a cross-over design.

NCT ID: NCT00755521 Recruiting - Fibromyalgia Clinical Trials

Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia

Start date: September 2008
Phase: Phase 4
Study type: Interventional

The main of the proposed study is to assess whether the use of the Cox-2 inhibitor Etoricoxib is beneficial for the use in fibromyalgia. We intend to seek whether this medication may improve psychiatric and rheumatologic parameters of the disease.

NCT ID: NCT00498264 Recruiting - Fibromyalgia Clinical Trials

Effectiveness of Physical Exercise in Women With Fibromyalgia

Start date: January 2005
Phase: Phase 2
Study type: Interventional

Fibromyalgia (FMS) is a syndrome expressed by chronic widespread body pain which leads to reduced physical function and frequent use of health care services. Exercise training is commonly recommended as a treatment. The purpose of this study is to determine whether a supervised resistance muscular exercise (RME) and walking program (WP) are effective in the treatment of FMS on decrease of pain. The practical of the RME reduces the pain of participants with FMS.

NCT ID: NCT00222209 Recruiting - Fibromyalgia Clinical Trials

Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain

Start date: September 2005
Phase: N/A
Study type: Interventional

The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. We, the researchers at University Hospital Mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. Somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.