Fever Clinical Trial - Treatment Of Fever In The Emergency Department

Status Completed

Clinical Trial Summary

Fever is a frequent cause of admission to the Emergency Department (ED) around the world. While it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined. This observational, prospective, single-center study enrolled adult patients who accessed the ED for fever, with the aim to define the most effective treatment for them.

Clinical Trial Description

Physicians were free to administer paracetamol 1000 mg (P), the combination paracetamol 500 mg/ibuprofen 150 mg (PI) or Ibuprofen 600 mg (I).The primary endpoint was both 1-degree and 1-point reduction in body temperature for all associated symptoms on the Numeric Rating Scale (NRS) after 1 hour (T1). Secondary endpoint was the reduction of at least 2 points on the NRS after two hours (T2). Adverse events, the needing of a rescue therapy and the response based on the underlying etiology (bacterial, viral, or immune/neoplastic) were also evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05814302
Study type	Observational
Source	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact
Status	Completed
Phase
Start date	June 1, 2021
Completion date	July 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02948283` - Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia	Phase 1
Completed	`NCT03706599` - Fever Infants and Therapeutic Education in Emergency Department	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Not yet recruiting	`NCT01782183` - Thermographic Characteristics of Sore Throat by Thermographic Camera	N/A
Withdrawn	`NCT00800696` - Preventive Oral Care	N/A
Completed	`NCT02689193` - IDIS Project Work Package 2: Establishing a Biobank at ITM and Collaborating Centres
Completed	`NCT02212990` - The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine	N/A
Completed	`NCT01869699` - Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults	Phase 4
Completed	`NCT01911143` - A Retrospective, Blinded Validation of a Host-response Based Diagnostics	N/A
Completed	`NCT01559675` - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery	N/A
Completed	`NCT01194557` - Introducing Rapid Diagnostic Tests Into the Private Health Sector	N/A
Completed	`NCT00940654` - The Fever and Antipyretic in Critically Illness Evaluation Study	N/A
Completed	`NCT00969176` - Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates	Phase 2/Phase 3
Recruiting	`NCT00729976` - Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study.	Phase 4
Recruiting	`NCT00389272` - Adding a Second Drug for Febrile Children Treated With Acetaminophen	N/A
Completed	`NCT00257790` - The Tobramycin Study	Phase 4
Recruiting	`NCT05033613` - Home Blood Pressure Monitoring Before and After COVID-19 Vaccination in Patients at High Risk of Cardiovascular Disease
Completed	`NCT02595827` - Non-inferiority Trial of Conditional vs Universal Follow up for Children With Fever in Democratic Republic of Congo	Phase 3
Recruiting	`NCT06061575` - Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients	Phase 4
Recruiting	`NCT06038617` - Safety of Simultaneous mRNA COVID-19 Vaccine With Other Childhood Vaccines in Young Children	Phase 4