The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine

Fever Clinical Trial

Official title:

Clinical Immunization Safety Assessment (CISA): A Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine (IIV) Administered to Children 6 Through 47 Months of Age

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02212990
• Other study ID #: Pro00056213
• Secondary ID: 200-2012-53663
• Status: Completed
• Phase: N/A
• First received: August 7, 2014
• Last updated: February 5, 2018
• Start date: September 2014
• Est. completion date: March 2016

Study information

• Verified date: April 2016
• Source: Duke University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to conduct a double-blind, placebo-controlled study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 6 through 47 months of age.

In this study, 160 healthy children, 6 through 47 months of age, including some children at risk of febrile seizure, will be randomized to one of three different treatment arms. Children will receive either blinded therapy with prophylactic acetaminophen or placebo immediately following and every 4 to 6 hours in the 24 hours after receipt of a dose of IIV or open-label ibuprofen every 6 to 8 hours in the 24 hours after receipt of a dose of IIV. Children will be followed for the occurrence of fever, fussiness, changes in appetite and sleep patterns, and use of medical services on the day of and for two days following vaccination. Antibody to influenza antigens contained in the respective 2014-2015 and 2015-2016 vaccines as measured by hemagglutination inhibition (HAI) antibody will be assessed at baseline and four weeks following vaccination. The proportions of children experiencing fever, having solicited side effects, using medical services, demonstrating a serologic response corresponding to seroprotection and seroconversion to each of the IIV antigens will be determined for groups of children in each of the three treatment arms. Likewise geometric mean HAI titers (GMTs) and corresponding 95% confidence intervals for each IIV antigen will be calculated for the three treatment arms. The investigators hope to learn whether or not prophylactic antipyretics affect the immune response and fever rates following IIV.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 104
• Est. completion date: March 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Months to 47 Months

Eligibility

Inclusion Criteria:

1. The child must be 6 through 47 months of age.

2. The child must weigh 5.4 kilograms.

3. The child must be receiving IIV this season.

4. If the child is two years of age or older and needs two doses of influenza vaccine this season the parent/guardian intends for the child to receive IIV for the second dose.

5. The parent/guardian must be willing and capable of providing written informed consent for the child.

6. The parent/guardian must be available for follow-up and must at minimum have telephone access.

7. The parent/guardian must agree to sign a medical release for the child so that study personnel may obtain medical information about the child's health (if needed).

Exclusion Criteria:

1. History of receipt of current year's licensed influenza vaccine.

2. Planned receipt of the live attenuated nasally administered influenza vaccine this year

3. History of a severe allergic reaction (e.g. anaphylaxis) to any component of influenza vaccine, including egg protein, formaldehyde, octylphenol ethoxylate, gelatin, or thimerosal if using thimerosal containing vaccine.

4. History of a severe allergic reaction (e.g. anaphylaxis) following a prior dose of influenza vaccine.

5. History of an allergic reaction following acetaminophen or ingredients in the acetaminophen product.

6. History of an allergic reaction following ibuprofen or ingredients in the ibuprofen product.

7. History of an allergic reaction following aspirin or other pain reliever or fever reducer.

8. History of liver disease.

9. Currently taking the blood thinning drug warfarin (Coumadin) or other blood thinners.

10. History of recent or planned heart surgery within the past 3 months or next 3 months.

11. History of stomach ulcer or bleeding problem.

12. Currently already routinely taking prescription or nonprescription non-steroidal anti-inflammatory drugs or NSAIDs (aspirin, ibuprofen, naproxen, or others)

13. Received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to vaccination in this study or expects to receive a licensed vaccine during the 28 days following the last influenza vaccination in this study. Concomitant vaccinations are not allowed.

14. Routine immunizations are delayed or will be delayed by not being able to receive a concomitantly administered vaccine or a needed vaccine in the 28 days following the last influenza vaccination in this study.

15. Received an experimental/investigational agent (vaccine, drug, biologic, device, blood product, or medication) within 28 days prior to vaccination in this study, or expects to receive an experimental/investigational agent within the follow-up time period (28 days after the last vaccination in this study).

16. A moderate to severe acute illness and/or a reported temperature greater than or equal to 100.0°F (37.8°C) within 72 hours prior to first dose of IIV or an axillary temperature greater than or equal to 100.0°F (37.8°C) at the time of enrollment. (This may result in a temporary delay of vaccination. For those needing a second dose of IIV, a moderate to severe acute illness and/or a reported temperature greater than or equal to 100.0°F (37.8°C) within 72 hours prior to second dose of IIV may result in a temporary delay of vaccination).

17. Receipt of an antipyretic medication (acetaminophen or ibuprofen) within 72 hours prior to the first dose of IIV (This may result in a temporary delay of vaccination) or is already planning to administer a prophylactic antipyretic medication on the day of and the day following any dose of IIV (this exclusion does not apply if the caretaker indicates he/she might administer antipyretics after vaccination to reduce a fever).

18. Immunosuppression as a result of an underlying illness or treatment, or use of anti-cancer chemotherapy or radiation therapy within the preceding 36 months.

19. Long term (at least 14 days of prednisone 2 mg/kg/day or equivalent other glucocorticoid), any parenteral steroids, high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months (topical and nasal steroids are allowed).

20. History of Guillain-Barré syndrome within 6 weeks of a prior dose of influenza vaccine.

21. Has any condition that would, in the opinion of the site investigator, place the participant at an unacceptable risk of injury or render the participant unable to meet the requirements of the protocol.

Related Conditions & MeSH terms

• Fever
• Influenza, Human

Intervention

Other:
• Acetaminophen Arm
Blinded Therapy
• Placebo Arm
Blinded Therapy
• Ibuprofen Arm
Open Label Therapy

Locations

Country	Name	City	State
United States	Duke University Health System	Durham	North Carolina

Sponsors (2)

Lead Sponsor	Collaborator
Duke University	Centers for Disease Control and Prevention

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Fever	Proportions of children with fever (= 38°C and = 39°C) on days 0, 1, and 2 following IIV	Days 0, 1, and 2 following IIV
Other	Systemic symptoms following IIV	Proportions of children with fussiness, appetite change, or altered sleep on days 0, 1, and 2 following IIV	Days 0, 1, and 2 following IIV
Other	Receipt of medical attention	Proportions of children receiving medical attention on days 0, 1, and 2 following IIV	Days 0, 1, and 2 following IIV
Primary	Seroconversion	Seroconversion (an HAI titer = 1:40 four weeks post- vaccination if the baseline titer is < 1:10 or a four-fold rise in HAI titer if the baseline titer is = 1:10) for each IIV antigen	One month following the last dose of IIV
Secondary	Seroprotection	Seroprotection (the proportion of subjects with an HAI titer >1:40) to each IIV antigen	One month following the last dose of IIV
Secondary	Geometric mean HAI titer	Geometric mean HAI titer (GMT) and 95% confidence interval for each IIV antigen	One month following the last dose of IIV