A Cohort of Severe Placental Fetal Growth Restriction (CoSFGR)

Status Recruiting

Clinical Trial Summary

Through multicenter study, the investigators aim to refine the process for precise prenatal diagnosis of fetal growth restriction (FGR), establish a cohort for severe maternal vascular malperfusion (MVM)-FGR, and conduct follow-up study to identify prognostic factors associated with both short-term and long-term outcomes.

Clinical Trial Description

FGR refers to the inadequate growth of the fetus due to various pathological factors, and is a major cause of morbidity and mortality in neonates, with close link to adverse long-term outcomes. This cohort will based on the establishment of a precise prenatal diagnostic process for FGR, and aims to establish a cohort for severe MVM-FGR. Severe singleton FGR cases (EFW or AC<3%, or EFW<10% with abnormal doppler blood flow) from multiple centers will be included. Prenatal genetic and microbial testing, and ultrasound will be performed to rule out associated fetal factors. Fetal intrauterine status will be closely monitored and assessed during pregnancy, with follow-up studies conducted up to 2 years of age. Pathological examination of the placenta will be conducted after delivery, with genetic testing when necessary. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06104748
Study type	Observational [Patient Registry]
Source	Shanghai First Maternity and Infant Hospital
Contact	Jianping Chen, Master
Phone	+86 13916159565
Email	urchin_chen@163.com
Status	Recruiting
Phase
Start date	August 10, 2023
Completion date	December 30, 2025

View Details

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