Fetal Growth Restriction Clinical Trial
Official title:
Femur Length to Mid-thigh Circumference Ratio in Prediction of IUGR
One of the most challenging areas currently facing obstetricians is the detection and
management of pregnancies in which the growth of the fetus is poor. These fetuses have not
only increased rates of perinatal morbidity and mortality, but also have higher levels of
morbidity extending into adult life (Linda; Murray 2010).
In developing countries including Egypt, low birth weight is a national concern and
emphasized in population and health policies according to the latest WHO data published in
April 2011 low Birth Weight Deaths in Egypt reached 13,587 or 3.74% of total deaths,
Mortality was more frequent in LBW (31.6%) than normal birth weight (NBW) infants (2.0%).
Fetal growth restriction (FGR) is defined as fetuses whose growth velocity slows down or
stops completely because of inadequate oxygen and nutritional supply or utilization (Linda;
Murray 2010). Low birth weight (LBW) refers to an infant with a birth weight < 2500 g, Small
for gestational age (SGA) birth is defined as an estimated fetal weight (EFW) less than the
10th centile and severe SGA as an EFW less than the 3rd centile, (RCOG Green-top Guideline
No.31, 2013).
Ultrasound has been used as a tool for determining fetal health and a variety of sonographic
parameters have been used to screen and diagnose IUGR including fetal biometry, fetal body
proportions (Campbell et al., 1994), amniotic fluid volume (Owen et al., 1999), subcutaneous
tissue thickness and estimated fetal weight (EFW) (Larciprete et al., 2005).
IUGR is associated with changes in the body proportions as undernourished fetus directs most
of its energy to maintain the growth of vital organs, such as the brain and heart, at the
expense of the liver, muscle and fat and this results in decreased abdominal and thigh
circumference measurements and hence theoretically increased HC/AC, FL/AC and FL/TC ratios
(Colley et al., 1991).
Fetal thigh circumference has a role to play in accurately measuring fetal weight when
incorporated with other fetal parameters and provide a potentially straightforward method
for assessing the deposition of muscle and fat in the growing fetus; there is a scope of
using the FL/TC ratio in predicting IUGR (Sanyal et al., 2012).
Fetal thigh circumference to femur length ratio (FL/TC) seems to be potential for use in
predicting IUGR (Shripad; Varalaxmi, 2005).
Aim of work To determine usefulness of antenatally measured femur length to mid thigh
circumference ratio to predict intra-uterine growth restricted fetuses.
Study design Observational Case-Control study. Study population This study will be conducted
at the department of Obstetrics and Gynecology recruiting pregnant women selected from the
attendees of antenatal clinic, emergency department and from inpatient wards of Ain Shams
University Maternity Hospital from the period of October 2013 to October 2014.
This study will include 100 pregnant women these cases will divided into 2 groups:
1. Normal growth Fetuses Group: will include 50 pregnant females all in third trimester.
2. IUGR fetuses Group: will include 50 pregnant females all in third trimester.
Inclusion criteria:
1. all pregnant women aged between 20-40 years ,
2. Singleton pregnancy,
3. Gestational age of 28-40 weeks, and
4. Reliable dates by early antenatal ultrasound.
Exclusion criteria:
1. Ultrasonographically detected congenital fetal malformation,
2. Fetal hydrops,
3. Multiple pregnancy,
4. Post-term pregnancy,
5. Intrauterine fetal death.
;
Observational Model: Case Control, Time Perspective: Prospective
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