Fertilization in Vitro and Blood Coagulation Factors Clinical Trial
Since its introduction in 1978, over 3.75 million babies have been born using in vitro
fertilization (IVF). Maturing ovarian follicles lead to a large rise in estrogen to
supra-physiological levels . This increase in estrogen has been shown to cause a
hypercoagulable state, leading at times to arterial and venous thrombosis.(Thromboelastogram
(TEG) is a point of care whole blood hemostatsis analyzer mimicking in vivo conditions and
measuring visco elastic properties of the clot. The TEG shows effect of most of the
components of hemostatsis: coagulation factors, fibrinogen, platelets and fibrinolysis.
Components of TEG include R, reflecting coagulation factor cascade, alpha angle and K
measurements reflecting fibrin function, MA reflecting mostly thrombocyte function,
coagulation index (CI) measuring global hemostatic statis and LY30 measuring fibrinolysis.
In this study the investigators would like to measure serum estrogen levels and (TEG) in
parturients at the beginning and conclusion of an IVF simulation cycle and evaluate how it's
influnence on coagulation parameters, and wheather or not a large sample size will effect
primary outcomes.
Secondarily the investigators would like to see if estrogen levels are predictors of
coagulation parameters and see if age influences TEG parameters
n/a
Observational Model: Cohort, Time Perspective: Prospective