Cancer Clinical Trial
Official title:
Methods for Fertility Preservation: Impact of Vitrification on in Vitro Matured Oocytes
During the last decades, there was an improvement of the cancer treatments of the woman and
the teenagers. Therefore higher survival rate is described. However, cancer treatments can
alter the reproduction functions and reduce considerably the window of the fertility to the
adulthood. Therefore, it is recommended to proceed to a fertility preservation by oocytes
vitrification when it is possible. The vitrification is a freezing technique allowing high
survival rate and similar results by assisted reproductive technologies compared with the use
of fresh oocytes. An innovative method of automated vitrification was recently developed. The
usual protocol consist to vitrify mature oocytes. However, this strategy cannot be used for
hormone -sensitive cancer or when ovarian stimulation is not possible. In these situations,
immature oocytes can be collected. It is also necessary to realize an in vitro maturation
step for a use by assisted reproductive technology.
According to the recent data of the literature, it remains unclear whether the vitrification
of ovocytes must be performed before or after in vitro maturation (IVM). Therefore the aim of
this study is to study the impact on structure and functions of ovocytes when vitrification
is performed before or after IVM. The vitrification will be performed by a semi-automatic
method which is an innovative method.
To perform this study, investigator will compare three groups. Group 1: immature ovocytes
vitrified before IVM; Group 2: immature oocytes vitrified after IVM; Group3: fresh immature
oocytes treated by IVM (without vitrification, control group).
The immature oocytes provide from ICSI patients. In routine these oocytes (germinal vesicle)
are normally destroyed because they cannot be used for injection. The women will give an
informed and written consent. Inclusion criteria are women less 37 years without
dysovulation.
The vitrification will be performed with the semi-automatic method (Gavi, Merck). The kinetic
and maturation rate will be analysed by time lapse (Primovision, Vitrolife) In the mature
oocytes, the actin and tubulin cytoskeleton, the spindle organization and the cortical
granules will be studied by immunofluorescence and 3D confocal microscopy. The expression of
maternal factors transcription will be analyzed by RT-PCR. The ploidy will be analysed by
multiFISH and/or CGH array.
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