Fertility Issues Clinical Trial
Official title:
Investigating Male Factors and Their Relationships With Reproductive Health Outcomes in Singapore: Towards Optimal Fertility, Fathering and Fatherhood studY
This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics.
Paternal contributions to fertility and reproductive health outcomes have been understudied, despite promising evidence from animal studies. This study aims to investigate the male contribution to pregnancy likelihood and explore the underlying biological mechanisms. Specifically, the investigators aim to (1) identify male factors associated with pregnancy rate; (2) develop a fertility index combining modifiable factors for both males and females to predict pregnancy rate; and (3) explore the relationship of male modifiable factors with semen physical and molecular characteristics. This is a case-control study with 480 fertile and subfertile males (along with their female partners), recruited from KK Women's and Children's Hospital. The investigators will use questionnaires to collect data on socio-demographic characteristics, clinical, lifestyle, and environmental factors; analyze metabolic and stress biomarkers from blood samples; and measure semen parameters including sperm motility, density, morphology, volume, DNA fragmentation, DNA methylation, gene expression, and seminal plasma oxidative status. Findings from this proposed study will pave the way for developing lifestyle-based or medical interventions to enhance male and couple reproductive health, and potentially benefiting future offspring health. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04519593 -
ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma
|
N/A | |
| Recruiting |
NCT05980091 -
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
|
Phase 1 | |
| Recruiting |
NCT06043609 -
Outcome Evaluation After Fertility Preservation
|
||
| Not yet recruiting |
NCT05048771 -
Fertility and Temporality in Pediatric Oncology
|
||
| Completed |
NCT05368194 -
Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins
|
N/A | |
| Recruiting |
NCT05176535 -
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
|
N/A | |
| Recruiting |
NCT06360471 -
Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer
|
||
| Recruiting |
NCT05271981 -
Fertility After Uterine Artery Embolization
|
||
| Recruiting |
NCT05815719 -
Continuous Double Ovarian Stimulation.
|
Phase 4 | |
| Recruiting |
NCT06127875 -
Effects of Trying to Conceive Using an Home- or Hospital-based Ovulation Monitoring on Stress
|
||
| Recruiting |
NCT05658848 -
Effect of Collaborative Infertility Counseling on Coping Strategies and Marital Satisfaction
|
N/A | |
| Not yet recruiting |
NCT05385848 -
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
|
N/A | |
| Completed |
NCT04396210 -
Patients Perspectives on Discontinuation of Their Fertility Treatment Due to the COVID-19 Pandemic
|
||
| Completed |
NCT05134090 -
Percutaneous Laparoscopy for Ovarian Tissue Cryopreservation.
|
||
| Completed |
NCT05905289 -
Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors
|
||
| Recruiting |
NCT05316467 -
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
|
Phase 2/Phase 3 | |
| Completed |
NCT04600869 -
Effects of Naturalistic Decision-Making Model-based Oncofertility Care Education
|
N/A | |
| Withdrawn |
NCT04683237 -
Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT06179420 -
The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment
|
||
| Recruiting |
NCT06163079 -
Assisted Reproductive Techniques (ART) With Sperm Donation : an Inclusive Model of ART for All Women
|