Fertility Issues Clinical Trial
Official title:
Continuous Ovarian Stimulation in DUOSTIM Cycles.
To evaluate the efficacy of the weekly use of corifollitropin alfa in double ovarian stimulation process and to compare it to the conventional protocol with daily medication administration.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | May 30, 2023 |
Est. primary completion date | April 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 43 Years |
Eligibility | Inclusion Criteria: - Patients with indication for DUOSTIM protocol - Maximum age of 43 years (up to one day before their 44th birthday) at the beginning of the stimulation process. - Ability to participate and comply with the study protocol. - To have given written consent Exclusion Criteria: - Finding of ovarian pathology at the time of initiation of stimulation: e.g. ovarian cysts. - Concurrent participation in another study. |
Country | Name | City | State |
---|---|---|---|
Spain | Instituto Bernabeu | Alicante |
Lead Sponsor | Collaborator |
---|---|
Instituto Bernabeu |
Spain,
Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003 Sep;69(3):1023-31. doi: 10.1095/biolreprod.103.017772. Epub 2003 May 14. — View Citation
Devroey P, Boostanfar R, Koper NP, Mannaerts BM, Ijzerman-Boon PC, Fauser BC; ENGAGE Investigators. A double-blind, non-inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH anta — View Citation
Kuang Y, Chen Q, Hong Q, Lyu Q, Ai A, Fu Y, Shoham Z. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod Biomed Online. 2014 Dec;29(6):684-91. doi: 10.1016/j.rbmo.2014.08.009. — View Citation
Kuang Y, Hong Q, Chen Q, Lyu Q, Ai A, Fu Y, Shoham Z. Luteal-phase ovarian stimulation is feasible for producing competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in fr — View Citation
Vaiarelli A, Cimadomo D, Petriglia C, Conforti A, Alviggi C, Ubaldi N, Ledda S, Ferrero S, Rienzi L, Ubaldi FM. DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF pu — View Citation
Vaiarelli A, Cimadomo D, Trabucco E, Vallefuoco R, Buffo L, Dusi L, Fiorini F, Barnocchi N, Bulletti FM, Rienzi L, Ubaldi FM. Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | number of retrieved oocytes - study group | To investigate the total number of oocytes retrieved through ovarian stimulation in double ovarian stimulation (DUOSTIM) cycles utilizing weekly subcutaneous injections of Corifollitropin alfa during DUOSTIM stimulation | Through study completion, an average of four months | |
Primary | number of retrieved oocytes - comparison | To compare the total number of oocytes obtained in the study group with the outcomes of historical data collected from conventional DUOSTIM cycles that employed the conventional protocol (consisting of daily subcutaneous injections of gonadotropins). | Through study completion, an average of four months | |
Secondary | number of MII oocytes - comparison | To assess whether there exist any differences between the two groups with respect to the rate of metaphase II (MII) oocytes. | Through study completion, an average of four months | |
Secondary | duration of DUOSTIM cycle - comparison | To assess whether there are differences between the two groups concerning the duration of stimulation. | Through study completion, an average of four months | |
Secondary | fertilization rate - comparison | To assess whether there are differences between both groups regarding the fertilization rate. | Through study completion, an average of four months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06387498 -
Testicular Tissue Cryopreservation (TTC)
|
N/A | |
Recruiting |
NCT04519593 -
ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma
|
N/A | |
Recruiting |
NCT05980091 -
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
|
Phase 1 | |
Recruiting |
NCT06043609 -
Outcome Evaluation After Fertility Preservation
|
||
Not yet recruiting |
NCT05048771 -
Fertility and Temporality in Pediatric Oncology
|
||
Completed |
NCT05368194 -
Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins
|
N/A | |
Recruiting |
NCT05176535 -
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
|
N/A | |
Recruiting |
NCT06360471 -
Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer
|
||
Recruiting |
NCT05271981 -
Fertility After Uterine Artery Embolization
|
||
Recruiting |
NCT06127875 -
Effects of Trying to Conceive Using an Home- or Hospital-based Ovulation Monitoring on Stress
|
||
Recruiting |
NCT05658848 -
Effect of Collaborative Infertility Counseling on Coping Strategies and Marital Satisfaction
|
N/A | |
Not yet recruiting |
NCT05385848 -
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
|
N/A | |
Completed |
NCT04396210 -
Patients Perspectives on Discontinuation of Their Fertility Treatment Due to the COVID-19 Pandemic
|
||
Completed |
NCT05134090 -
Percutaneous Laparoscopy for Ovarian Tissue Cryopreservation.
|
||
Completed |
NCT05905289 -
Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors
|
||
Recruiting |
NCT05316467 -
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
|
Phase 2/Phase 3 | |
Completed |
NCT04600869 -
Effects of Naturalistic Decision-Making Model-based Oncofertility Care Education
|
N/A | |
Withdrawn |
NCT04683237 -
Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT06179420 -
The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment
|
||
Recruiting |
NCT06163079 -
Assisted Reproductive Techniques (ART) With Sperm Donation : an Inclusive Model of ART for All Women
|