ASA 81 mg vs 162 mg During Frozen Embryo Transfer (FET)

Fertility Disorders Clinical Trial

Official title:

Retrospective Study to Assess if Aspirin 162 mg is Better Than 81 mg for Embryo Transfer Outcomes

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06128395
• Other study ID #: 3384
• Status: Active, not recruiting
• Start date: November 1, 2023
• Est. completion date: October 30, 2024

Study information

• Verified date: November 2023
• Source: Clinique Ovo
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The use of low dose aspirin is recommended for high risk patients to reduce the risk of pre-eclampsia, placental abruption and antepartum hemorrhage. Recent studies have shown that in a specific population, the use of low dose aspirin might reduce the risk of preterm birth in pregnant women with singleton pregnancy. In June 2022, clinique ovo started implementing the use of Aspirin 162 mg instead of 81 mg in the frozen embryo transfer cycles based on recent study outcomes. The use of Aspirin 162 mg might have additional benefits on the embryo transfer outcomes by decreasing the miscarriage. Moreover this can be continued until late in pregnancy without adverse effects.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 500
• Est. completion date: October 30, 2024
• Est. primary completion date: August 30, 2024
• Gender: Female
• Age group: N/A to 40 Years

Eligibility

Inclusion Criteria:

• Women taking aspirin 81 mg or 162 mg prior to an autologous embryo transfer

• Age < 40 years old

• Embryo transfer cycle done at clinique ovo

Exclusion Criteria:

• Egg or embryo recipient

• History of recurrent miscarriages, defined as = 3 consecutive losses

• Patients that needed Viagra, PRP or other modalities to improve their endometrial thickness

• Uterine factor infertility

• Abnormal hormonal profiles

• Stimulated embryo transfer cycles

• History of recurrent implantation failure defined as failed = 2 euploid embryos transfer or = 3 blastocysts

Related Conditions & MeSH terms

• Fertility Disorders

Intervention

Other:
• Frozen embryo transfer
A frozen embryo transfer involves thawing a fertilized embryo and transferring it in the uterus in order to obtain a pregnancy

Locations

Country	Name	City	State
Canada	Clinique Ovo	Montreal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Clinique Ovo

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Compare clinical pregnancy rate between patients prescribed Aspirin 81 mg vs Aspirin 162 mg	clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound	Time Frame: 6 to 8 weeks after Frozen Embryo Transfer