Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)

Fertility Disorders Clinical Trial

Official title:

Embryo Transfer in Natural vs Substituted Cycle and the Scheduling Pattern of IVF

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06053827
• Other study ID #: 3356
• Status: Active, not recruiting
• Start date: September 19, 2023
• Est. completion date: September 30, 2024

Study information

• Verified date: January 2024
• Source: Clinique Ovo
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready. In contrast, in frozen embryo transfer natural cycle patients are not taking any hormones, only triggered with hCG (human chorionic gonadotropin) when a dominant follicle is ready or they wait for the disappearance of the dominant follicle to plan the transfer date. Some doctors and centres shift towards using the substituted protocol in an attempt to make scheduling easier with less frequent ultrasounds. This study will aim to compare clinical and biochemical pregnancy rates in patients who underwent frozen embryo transfers in natural cycles vs substituted cycles at the centre.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 500
• Est. completion date: September 30, 2024
• Est. primary completion date: November 30, 2023
• Gender: Female
• Age group: N/A to 40 Years

Eligibility

Inclusion Criteria:

• Age < 40 years old
• Women having undergone either a frozen embryo transfer in natural cycle or substituted cycle
• IVF and FET cycles done at Clinique OVO

Exclusion Criteria:

• egg or embryo recipient
• History of recurrent miscarriages, defined as = 3 consecutive losses
• Patients that needed Viagra, Plasma-Rich Platelet (PRP) or other modalities to improve their endometrial thickness
• Uterine abnormalities
• Abnormal hormonal profiles
• FET Stimulated cycles
• History of recurrent implantation failure defined as failed = 2 euploid embryos transfer or = 3 blastocysts

Related Conditions & MeSH terms

• Fertility Disorders

Intervention

Other:
• Frozen embryo transfer
A frozen embryo transfer involves thawing a fertilized embryo and transferring it in the uterus in order to obtain a pregnancy

Locations

Country	Name	City	State
Canada	Clinique Ovo	Montréal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Clinique Ovo

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluate the clinical pregnancy rate of embryo transfer in natural vs substituted cycles	clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound	6 to 8 weeks after Frozen Embryo Transfer