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Fertility Disorders clinical trials

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NCT ID: NCT06304220 Not yet recruiting - Infertility, Female Clinical Trials

Comparison of Two PPOS Models for Pituitary Suppression

Start date: April 2024
Phase: N/A
Study type: Interventional

The scarcity of evidence regarding the interchangeable use of different progestogens poses challenges, particularly in international egg donation and fertility preservation programs where standardizing protocols is crucial for achieving consistent efficacy, efficiency, and safety outcomes. Consequently, there's a pressing need for clinical studies to assess the effects of various progestogens on clinical outcomes in controlled ovarian hyperstimulation cycles. This study, a pioneering effort, aims to compare the effects of two progestogens on oocyte performance, safety, and efficiency in an egg donation program involving young, healthy, normo-responding patients.

NCT ID: NCT06195163 Not yet recruiting - Fertility Disorders Clinical Trials

TRAP Study: Testosterone for Androgen Receptor Polymorphism

TRAP
Start date: January 30, 2024
Phase: Phase 4
Study type: Interventional

To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen receptor polymorphism undergoing intracytoplasmic sperm injection (ICSI).

NCT ID: NCT05412147 Not yet recruiting - Infertility, Female Clinical Trials

The Effect of RECO-18 on Infertile Women Undergoing in Vitro Fertilization-embryo Transfer

Start date: July 2022
Phase: N/A
Study type: Interventional

How to improve the fertility of infertile women has become a hot topic in the field of assisted reproduction. Animal experiment has shown that RECO-18 significantly improved the female fertility in mice, and the specific mechanism was related to reducing follicular atresia, promoting follicle development and improving oocyte quality. Therefore the investigators aim to conduct a pilot study to explore the effect of RECO-18 in infertile women undergoing assisted reproduction treatment. This study is a prospective, randomized, controlled clinical study. The treatment group takes RECO-18 while the control group takes the multi-vitamins. The primary indicator is the ongoing pregnancy rate at 12 weeks' gestation; the secondary indicators are the number of oocytes retrieved, the normal fertilization rate and the rate of high quality embryos, implantation rate, clinical pregnancy rate, and early miscarriage rate.

NCT ID: NCT05164029 Not yet recruiting - Fertility Disorders Clinical Trials

The Clinical Cohort Study of Reproductive Health

Start date: January 1, 2022
Phase:
Study type: Observational [Patient Registry]

The study will conduct a multicenter prospective clinical cohort study to collect comprehensive health information and essential specimens from pre-pregnancy to postpartum offspring development. We will combine the reproductive medicine with the big data technologies and cloud computing to explore the key factors which will induce the occurrence the reproductive disorders and effect the health of women and offspring. Based on the discovery of the cohort study, we will construct a prediction model for improvement of ART,optimizing the effectiveness and safety of ART.

NCT ID: NCT04850261 Not yet recruiting - Fertility Disorders Clinical Trials

Injection Free IVF

Start date: May 1, 2021
Phase: Phase 2
Study type: Interventional

Investigation of Natural Cycle In vitro Fertilisation (NC-IVF) treatment with ovulation induction with a nasal GnRH agonist instead of regular NC-IVF treatment with subcutaneous application of hCG with the objective of increasing treatment tolerability and reducing discomfort while being equally successful in terms of embryo transfer rates.

NCT ID: NCT04663971 Not yet recruiting - Ulcerative Colitis Clinical Trials

Fertility and Pregnancy After Surgery IBD Audit

Fertile-IBD
Start date: November 15, 2022
Phase:
Study type: Observational

Crohn's disease and Ulcerative colitis are chronic disease that are usually diagnosed at young age. The diseases and the associated treatment can impact on patient's sexual function, fertility, pregnancy, and delivery. This study aims to assess the impact of inflammatory bowel diseases on these aspects in female patients.

NCT ID: NCT04606082 Not yet recruiting - Fertility Disorders Clinical Trials

Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor in Increasing Pregnancy Rate in ICSI

Start date: October 30, 2020
Phase: N/A
Study type: Interventional

Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.

NCT ID: NCT04604054 Not yet recruiting - Fertility Disorders Clinical Trials

The Effect of Granulocyte Colony Stimulating Factor Versus Human Chorionic Gonadotropin in Females With a History of RIF

Start date: October 30, 2020
Phase: N/A
Study type: Interventional

One hundred patients who suffered from recurrent implantation failure in intracytoplasmic sperm injection (ICSI) were allocated in the study. On ovum pick-up day, 50 of them were intrauterine injected with granulocyte colony-stimulating factor (G-CSF) and the other 50 were injected with intrauterine Human Chorionic Gonadotropins (HCG). The clinical pregnancy rate was evaluated as a primary outcome and ultrasound imaging of the gestational sac was evaluated as a secondary outcome

NCT ID: NCT04589793 Not yet recruiting - Fertility Disorders Clinical Trials

COaching Lifestyle Intervention for FErtility

COLIFE
Start date: October 2021
Phase: N/A
Study type: Interventional

In Finland, every third woman is overweight (BMI>25) and 11,5% obese (BMI>30). Cohort and national studies reveal that 46% of fertile-aged men have BMI≥25 and 20% BMI≥30. Overweight has negative impact on both female and male fertility and weakens markedly the results of infertility treatments. In this study, 780 infertile couples will be randomized to control group (conventional infertility treatment) and lifestyle intervention arm undergoing 4 sessions of video-mediated motivational interview, anthropometric measurements, laboratory tests and epigenetic samples. Economic evaluation of the intervention will also be performed.

NCT ID: NCT03238092 Not yet recruiting - Fertility Disorders Clinical Trials

Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort

Start date: August 2017
Phase: Phase 3
Study type: Interventional

In vitro fertilization(IVF) with Gonadotropin-releasing hormone (GnRH) antagonist is one of the most used protocol for the treatment of infertile couples nowadays. Despite several advantages over GnRH agonist, the antagonist may be associated with a slightly reduction in pregnancy rates. Several medications have been tested in order to increase ovarian response to ovulation induction, including estradiol and testosterone. A clinical trial in women with IVF indication will be performed and this women will be randomly assigned to receive topic testosterone, oral estradiol or no pre-treatment prior to IVF with human Chorionic Gonadotropin (hMG) and GnRH antagonist. The primary endpoint will be the size and number of follicles on the beginning of the cycle, after pre-treatment.