Fentanyl-induced Coughing Clinical Trial
An intravenous bolus of fentanyl often induces a cough reflex. This study investigates whether priming with rocuronium can attenuate fentanyl-induced coughing effectively.
Fentanyl is widely used for analgesia and anesthesia because of its rapid onset, its intense
analgesic effect, and is associated with lessened cardiovascular depression and low
histamine release. Although the cough reflex is usually transient and self-limiting, it
should be avoided in situations such as elevated intracranial, intraocular, or
intra-abdominal pressure, and unstable hemodynamics.
The cause of FIC is unclear. One hypothesis is that vocal cord spasms might induce coughing
because of fentanyl-induced muscle rigidity and histamine release. Muscle relaxants are
commonly used to treat this condition. This study hypothesizes that priming muscle relaxants
could prevent or suppress FIC. This study investigates whether the muscle relaxant
rocuronium attenuates FIC effectively.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention