Fentanyl-induced Cough Clinical Trial
Official title:
Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough
The investigators aimed to investigate the effects of pretreatment with different doses of
dexmedetomidine on the cough caused by fentanyl during anesthetic induction.
Patients undergoing elective surgeries under general anesthesia will be randomly allocated to
4 groups (n = 60, each group). Dexmedetomidine 0, 0.03, 0.06, and 0.09 μg/kg/min will be
pump-administered in 10 mins to groups I, II, III, and IV, respectively, followed by the
induction of general anesthesia with intravenous fentanyl 4 μg/kg. The incidences and
severity of cough that occurred within 2 min after the injection of fentanyl will be
recorded, and the incidences of cardiovascular adverse events that occurred between the
administration of the dexmedetomidine infusion and 2 min after tracheal intubation will be
recorded.
n/a