Clinical Trials Logo

Clinical Trial Summary

The purpose of this prospective randomized study is to evaluate the risks and benefits of using bimodal analgesia, (i.e. Narcotics and NSAIDS) vs Narcotics alone post long bone fracture.


Clinical Trial Description

This will be a prospective, randomized, control trial looking at the benefit of bimodal analgesia in the treatment of long bone fractures. The traditional pain control regimen following fracture fixation typically involves a course of narcotics on an as-needed basis for pain relief. Recent data has shown that adding NSAIDS to the pain regimen as part of a bimodal approach to pain control, improves the efficacy of pain management and reduces narcotic use. Laboratory research on NSAIDs as it pertains to bone healing, however, has shown in animal models that there may be a positive association between NSAIDS and non-union rates. In other words, NSAIDS may prevent or delay bone healing. These results, however, have not been tested prospectively in humans.

The purpose of this study is to look at the combination of NSAIDS and narcotics post long bone fracture and monitor the effects on narcotic use and healing rates to ultimately and conclusively establish the risk or benefit of NSAIDS after long bone fracture. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00240396
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact
Status Withdrawn
Phase N/A
Start date October 2005
Completion date September 24, 2007

See also
  Status Clinical Trial Phase
Completed NCT03231787 - Clinical Trial in Antiaggregated Patients With Proximal Femur Fracture Evaluating a Strategy to Shorten Time Until Surgery N/A
Completed NCT00888160 - Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a Protocol for Early Appropriate Care
Recruiting NCT05613257 - Distal Targeter vs Free-hand N/A
Recruiting NCT01969279 - Radiographic Influences of Bisphosphonate Treatment on Femur N/A
Terminated NCT03160508 - Trochanter Fixation Nail Advanced (TFNA) Weight Bearing
Completed NCT04127045 - ProspEctive Cohort Study on Multidisciplinary Approach to Femur FRactures' manAgement in Over 65 Population
Recruiting NCT03868280 - The FLiP Study, a Pilot Cluster Randomized Trial N/A
Completed NCT00725894 - Pediatric Locking Nail for the Treatment of Femoral Fractures in Children N/A
Recruiting NCT04657510 - Femoral frACturEs and COVID-19.
Completed NCT05225753 - Post-operative Anemia in Lateral Fractures of the Femur.
Active, not recruiting NCT03775408 - FAST: Clinical Feasibility
Completed NCT02793947 - Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures Phase 4
Completed NCT00916136 - Skeletal Versus Cutaneous Traction For Treatment of Femur Fractures N/A
Completed NCT05183308 - Combined Drug Therapy in Lateral Fragility Fractures of the Femur
Not yet recruiting NCT00616044 - Continuous Spinal Anesthesia Versus Combined Spinal Epidural Block N/A
Terminated NCT01484405 - Anterolateral Versus Posterior Approach for Total Hip Arthroplasty After Displaced Femoral Neck Fracture N/A
Completed NCT00943332 - Pediatric Femur Research Project
Not yet recruiting NCT00686023 - Comparing Surgical Techniques for CRIF of Pertrochanteric Fractures N/A
Completed NCT01293916 - Spica Casting in Pediatric Femur Fractures: Study of Single Leg Versus Double Leg Spica Casts N/A
Completed NCT00593333 - Intramedullary Nailing of the Femur:Trochanteric vs Piriformis Starting Portals N/A