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NCT04988659 Clinical Trial

Analysis of Gene Expression in Femoroacetabular Impingement (FAI)

Femoroacetabular Impingement Clinical Trial

Official title:
Total Exon Association Analysis of Femoroacetabular Impingement (FAI)

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT04988659
Other study ID # M2020533
Secondary ID
Status Enrolling by invitation
Phase
First received
Last updated
Start date March 30, 2021
Est. completion date September 30, 2021

Study information
Verified date June 2021
Source Peking University Third Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Femoral acetabular impingement (FAI) is a common disease of the hip joint. In this study, whole-genome sequencing was used to further explore the pathogenesis of this disease.

Description:

Femoral acetabular impingement (FAI) is a group of chronic hip pain caused by the impact between the proximal femur and the edge of the acetabulum due to the anatomical abnormality of the hip joint, which damages the labrum and adjacent cartilage, and causes limited hip movement, especially limited flexion and internal rotation. However, the specific etiology of FAI is still unknown at present. The application of genome-wide, exon and transcription research methods to the study of hip impaction syndrome can uncover key differentially expressed genes and provide a theoretical basis for the study of FAI.

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 100
Est. completion date September 30, 2021
Est. primary completion date May 30, 2021
Accepts healthy volunteers
Gender All
Age group 15 Years to 70 Years
Eligibility Inclusion Criteria: - The patient underwent preoperative imaging and was diagnosed with FAI. The patient complained of pain in the hip, hip, or thigh, and had a positive hip flexion impact test. Exclusion Criteria: - Patients with hip surgery history, hip osteoarthritis, necrosis of the femoral head, hip infection, hip dysplasia and other hip diseases.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Exposures
Exposures

Locations
Country Name City State
China Peking University Third Hospital Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking University Third Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary The patients were clinically diagnosed with FAI (femoral acetabular impingement) and underwent arthroscopic surgery, then clinical samples were collected. Peripheral blood from 100 patients with femoral acetabular impingement syndrome was collected and DNA was extracted. The patient was diagnosed with FAI, and conservative treatment was ineffective for an average of 6 months.
See also
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Active, not recruiting NCT03891563 - Prospective Evaluation of Sport Activity and the Development of Femoroacetabular Impingement in the Adolescent Hip
Active, not recruiting NCT04069507 - Healthy Hip Study: Conservative Management for Pre-arthritic Hip Disorders
Terminated NCT03278353 - Fulfillment of Expectations for Patients With FAI Syndrome N/A
Terminated NCT03995290 - 3D Modeling to Improve Hip Arthroscopy Outcomes
Completed NCT06082271 - Comparative, Randomized Study on the Anti-inflammatory and Regenerative Efficacy of a New Medical Device (DM) Based on Hydrolyzed Collagen Peptides in Patients With Femoro-acetabular Impingement Undergoing Hip Arthroscopy N/A
Recruiting NCT01621360 - Hip Arthroscopy Versus Conservative Management of Femoroacetabular Impingement N/A
Completed NCT04980209 - The Feasibility and Application of Intraoperative Ultrasound to Evaluate Femoral Head Shaping
Active, not recruiting NCT03494660 - SCP Hip Outcomes Study
Active, not recruiting NCT04822571 - Investigating the Reliability of Highly Dynamic 3D Motion Analysis Protocol in Adolescence and Adult Males N/A
Withdrawn NCT02706756 - Conservative Intervention of Femoroacetabular Impingement Syndrome N/A
Completed NCT01814124 - Conservative Management of Femoroacetabular Impingement N/A
Completed NCT01993615 - A Physical Therapy Program Versus Surgery for Femoroacetabular Impingement: Randomized Clinical Trial N/A
Completed NCT02702661 - PRCT of FICB vs LAI for Hip Arthroscopy N/A