Senolytic Agent Improve the Benefit of Platelet-Rich Plasma & Losartan

Status Active, not recruiting

Clinical Trial Summary

The purpose is to explore the possible benefit of administration of Fisetin, (a senolytic agent) to improve the benefit of Platelet-Rich Plasma and losartan for treatment of femoroacetabular impingement and labral tear. We believe that giving Fisetin, a senolytic agent, will improve the benefit of PRP by eliminating senescent cells and senescence-associated secretory phenotype (SASP), known to exist in PRP. The main objectives of this study are to determine if pre- and post-operative administration of a senolytic agent will improve the beneficial effects of PRP when used in conjunction with surgical treatment of FAI and/or labral tear, to determine whether pre- and postoperative administration of Fisetin is associated with adverse events, and to determine if pre- and post-operative administration of Fisetin leads to a decrease in systemic senescence, serum SASP, and fibrotic markers. Patients suffering from femoroacetabular impingement and labral tear, who are planning to undergo hip arthroscopy combined with standard of care intra-operative PRP injection and post-operative losartan administration will be recruited from the clinical practice of the Principal Clinical Investigator or his designee at The Steadman Clinic (TSC).

Clinical Trial Description

This is a pilot, prospective, randomized, double-blind, placebo control clinical trial is proposed to evaluate the safety and efficacy of a senolytic agent (Fisetin) to improve the benefits of standard of care platelet rich plasma (PRP) injection and antifibrotic medication (Losartan) in patients undergoing hip arthroscopy for treatment of femoroacetabular impingement (FAI) and/or labral tear (LT). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05025956
Study type	Interventional
Source	Steadman Philippon Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 1/Phase 2
Start date	October 24, 2021
Completion date	October 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01623843` - Femoroacetabular Impingement RandomiSed Controlled Trial	N/A
Completed	`NCT03669471` - Muscular and Functional Performance in FAIS Patients
Not yet recruiting	`NCT05031390` - the Horsens Aarhus FemoroAcetabular Impingement Syndrome Training Pilot Study	N/A
Withdrawn	`NCT02674113` - Regional Anesthesia in Hip Arthroscopy	N/A
Withdrawn	`NCT02260726` - Evaluation of Ultrasound for Detecting Hip Impingement	N/A
Recruiting	`NCT05391204` - Reproducibility of Strength Testing and Functional Testing of the Hip for the Return to Sport of Patients Activated by a Femoroacetabular Impingement: Comparison Between a Group of Patients and a Group of Healthy Controls	N/A
Active, not recruiting	`NCT03891563` - Prospective Evaluation of Sport Activity and the Development of Femoroacetabular Impingement in the Adolescent Hip
Recruiting	`NCT04069507` - Healthy Hip Study: Conservative Management for Pre-arthritic Hip Disorders
Terminated	`NCT03278353` - Fulfillment of Expectations for Patients With FAI Syndrome	N/A
Terminated	`NCT03995290` - 3D Modeling to Improve Hip Arthroscopy Outcomes
Completed	`NCT06082271` - Comparative, Randomized Study on the Anti-inflammatory and Regenerative Efficacy of a New Medical Device (DM) Based on Hydrolyzed Collagen Peptides in Patients With Femoro-acetabular Impingement Undergoing Hip Arthroscopy	N/A
Recruiting	`NCT01621360` - Hip Arthroscopy Versus Conservative Management of Femoroacetabular Impingement	N/A
Completed	`NCT04980209` - The Feasibility and Application of Intraoperative Ultrasound to Evaluate Femoral Head Shaping
Enrolling by invitation	`NCT04988659` - Analysis of Gene Expression in Femoroacetabular Impingement (FAI)
Active, not recruiting	`NCT03494660` - SCP Hip Outcomes Study
Active, not recruiting	`NCT04822571` - Investigating the Reliability of Highly Dynamic 3D Motion Analysis Protocol in Adolescence and Adult Males	N/A
Withdrawn	`NCT02706756` - Conservative Intervention of Femoroacetabular Impingement Syndrome	N/A
Completed	`NCT01993615` - A Physical Therapy Program Versus Surgery for Femoroacetabular Impingement: Randomized Clinical Trial	N/A
Completed	`NCT02702661` - PRCT of FICB vs LAI for Hip Arthroscopy	N/A
Completed	`NCT01814124` - Conservative Management of Femoroacetabular Impingement	N/A

Senolytic Agent Improve the Benefit of Platelet-Rich Plasma and Losartan

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms