Femoro Acetabular Impingement Clinical Trial
Official title:
Prospective PROMs Outcomes in Arthroscopic Acetabular Labral Repair With and Without Application of Platelet-Rich Plasma (PRP) Harvested From the Body of the Ilium
Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and chondrolabral junction. Additionally, it has been proposed that disruption of hip biomechanics resulting from a labral tear causes a faster progression towards osteoarthritis (OA). This progression has been observed to begin with breakdown of the chondrolabral junction with later development of diffuse osteoarthritis. Use of hip arthroscopy has increased dramatically in recent years to treat symptomatic labral tears and potentially avoid the morbidity and cost associated with hip osteoarthritis. Correction of labral pathology presents a technical challenge and many techniques currently exist. Increased understanding of the structure-functional relationship dictated by labral anatomy has led to the development of methods aimed at restoring functional anatomy by re-establishing the labrum's native position and contour on the rim of the acetabulum. Therefore, akin to repairing a torn meniscus in the knee, restoring the anatomic footprint of a torn labrum will reconstitute normal joint biomechanics. Despite the advances in techniques for labral repair, strategies for mitigating or repairing damage to the chondrolabral junction do not yet exist. This area has been shown to consist of hyaline and fibro cartilage. Many techniques for cartilage repair exist, although most are not feasible due to technical challenges specific to the hip joint. The management of articular cartilage defects is one of the most challenging clinical problems for orthopaedic surgeons. Articular cartilage has a limited intrinsic healing capacity, and pathology frequently results in gradual tissue deterioration. Currently, the standard surgical intervention for end-stage degenerative joint pathology is total joint replacement. Early surgical interventions for symptomatic cartilage lesions including cell based therapies such as autologous chondrocyte implantation (ACI), bone marrow aspirate concentrate (BMAC) implantation, or microfracture have been suggested to restore normal joint congruity and minimize further joint deterioration. Techniques such as ACI, which have been successfully used in the knee joint, have limited application in the hip due to the technical difficulties of open procedures.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | June 30, 2026 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria and Rationale: 1. Age 18 or older: patients of any age have the capacity to potentially benefit from labral repair 2. Symptoms consistent with a tear of the acetabular labrum (i.e., catching, clicking, popping, pain with sitting, episodic pain, pain with hip flexion, adduction, and/or internal rotation): asymptomatic labral tears do exist in the general population however there is not definitive evidence to suggest treatment of asymptomatic tears is beneficial. 3. Symptoms not due to some other acute process in or around the hip (including septic arthritis, osteonecrosis, hemarthrosis, iliotibial band syndrome, fractures of the femoral neck or head, fractures of the acetabulum, greater trochanteric pain syndrome, sacroiliac joint pain, piriformis syndrome, low back pain associated with hip pain and not knee nor acute low back injury): certain conditions are not treatable by either arthroscopy or physical therapy. Some of these conditions can be managed with physical therapy but not arthroscopy. 4. Availability of hip radiographs and magnetic resonance imaging (MRI and/or MRA): needed to assess eligibility 5. Evidence of labral tear on MRI and/or MRA: documentation of acetabular labrum tear 6. Willingness to participate and ability to understand and sign informed consent document: ability to understand study and consent willingly 7. Returning subjects enrolled in protocol 2017P001391/PHS Exclusion Criteria and Rationale: 1. Non-English speaking subjects: PROMs are only validated in English. 2. Systemic infection: surgery is generally contraindicated when systemic infection is present. 3. Systemic heparinization: the vascularity of the bone and adjacent tissues is significant, posing a potential problem for bleeding when the patient is anti-coagulated. 4. Pregnant women/fetuses: although surgery can be performed on pregnant women, pregnant women are excluded under federal regulations. |
Country | Name | City | State |
---|---|---|---|
United States | MGH, Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
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Massachusetts General Hospital |
United States,
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* Note: There are 47 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change iHOT--33 Surveys from preoperative to various postoperative timepoints | Full Name of Outcome: International Hip Outcome Tool--33 Questions
Purpose: Validated Hip Patient Reported Outcome Measurements (PROMs) to assess the patient's functional outcomes post-surgery. Scale of iHOT-33: Min: 0 Max: 100 No standardized scoring categories (i.e. excellent, good, fair, poor). Higher score indicates better hip functionally. No subscores or subscales |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Change HOS Surveys from preoperative to various postoperative timepoints | Full Name of Outcome: HOS--Hip Outcome Score, which consists of two subscores: Hip Outcome Score-Activity of Daily Living (HOS-ADL), Hip Outcome Score-Sports Sub-scale (HOS-SSS)
Purpose: Validated Hip Patient Reported Outcome Measurements (PROMs) to assess the patient's functional outcomes post-surgery. Scale of HOS--ADL: Min: 0 Max: 68 Converted to a percentage, by dividing patient's score by 68. No standardized scoring categories (i.e. excellent, good, fair, poor). Higher score indicates better hip functionally. Scale of HOS--SSS: Min: 0 Max: 36 Converted to a percentage, by dividing patient's score by 36. No standardized scoring categories (i.e. excellent, good, fair, poor). Higher score indicates better hip functionally. |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Change NAHS Surveys from preoperative to various postoperative timepoints | Full Name of Outcome: Non-Arthritic Hip Score (NAHS)
Purpose: Validated Hip Patient Reported Outcome Measurements (PROMs) to assess the patient's functional outcomes post-surgery: Scale of NAHS: Min: 0 Max: 100 No standardized scoring categories (i.e. excellent, good, fair, poor). Higher score indicates better hip functionally. No subscores or subscales. |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Change LEFS Surveys from preoperative to various postoperative timepoints | Full Name of Outcome: Lower Extremity Functional Scale (LEFS)
Purpose: Validated Hip Patient Reported Outcome Measurements (PROMs) to assess the patient's functional outcomes post-surgery. Scale of LEFS: Min: 0 Max: 80 Converted to a percentage, by dividing patient's score by 80. No standardized scoring categories (i.e. excellent, good, fair, poor). Higher score indicates better hip functionally. No subscores or subscales |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Change mHHS Surveys from preoperative to various postoperative timepoints | Full Name of Outcome: modified Harris Hip Score (mHHS)
Purpose: Validated Hip Patient Reported Outcome Measurements (PROMs) to assess the patient's functional outcomes post-surgery. Scale of mHHS: Min: 0 Max: 100 Scoring of mHHS: Excellent: 90--100 Good: 80--89 Fair: 70--79 Poor: <70 Higher score indicates better hip functionally. No subscores or subscales. |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Change RAND-36 Surveys from preoperative to various postoperative timepoints | RAND-36 Measure of Health-Related Quality of Life (RAND 36 or SF 36):
The most widely used health-related quality-of-life survey instrument Consists of 36 questions that assess eight components of health: physical functioning, role limitation due to physical health problems, role limitations due to emotional problems, social functioning, emotional well-being, energy/fatigue, pain, and general health perceptions, with a simple mean of these responses ranging from 0 to 100, with 100 representing the best possible quality-of-life score. |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Degree of Improvement on Hip VAS Pain Score | At routine follow-up visits patients will be asked to rate hip pain using the VAS (Visual Analog Scale) Score
Min: 0--no pain Max: 10--worst pain experienced in their life Increments of 1. Categories: 1--3: mild pain 4--6: moderate pain 7--10: severe pain |
Baseline (pre-operative), 3 months, 6 months, 12 months, and annually thereafter | |
Secondary | Patient Satisfaction Questionnaires | Three Yes/No Questions:
Are you satisfied with the treatment you received? Are you satisfied with the treatment regimen that you were given? If given the choice in the future, would you choose the same treatment? |
12 months and annually thereafter |
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