Clinical Trials Logo

Clinical Trial Summary

The study is to examine whether the G-CBT for anorexia nervosa is effective or not. The study will use randomized controlled study design. 80 patients with AN will be recruited from Shanghai Mental Health Center, There will be two groups: CBT treatment group and conventional treatment group. Each group is 40 and then the CBT group will be given standard CBT intervention for 12 weeks. The control group will receive outpatient treatment. To assess the eating disorder symptoms, impulsive and emotional change, clinical symptom scales, psychological scales and the security indexs will be used at baseline, 4 weeks, 8 weeks, 12 weeks (end of treatment), 24 weeks (3 months after treatment) and 36 weeks (6 months after treatment follow-up).


Clinical Trial Description

Eating disorder is a chronic mental disorder characteristic of abnormal eating behaviors and psychological disorders, accompanied by significant weight changes and physiological dysfunction. Many people with EDs have cognitive disorder of their body shape or body weight. Anorexia is a subtype of EDs. The main feature of anorexia nervosa is the extreme attention to body weight and body shape. As a result of this conflict the patients could be malnutrition, metabolism and endocrine disorders with significant weight loss. And women may have amenorrhea. At the mean time, the patient will also have a lot of mental symptoms such as depression, anxiety and obsession.

The disease mostly occurs in adolescents and young women. The prevalence rates in Europe and America is 0.5%-3.7%, 90% of which are women. The course of the disease is chronic, the average duration of disease is 4-6 years. Furthermore the mortality rate is high, a 20-year follow-up data shows that the mortality rate is nearly 20%. Most of the causes of death are physical complications and depression.

However, due to the special psychological behavior mechanism, patients have almost no willingness to be treated. As well as the long duration of disease and the highrisk of drug therapy, it all causes the great difficulties in the treatment. Many patients may even suffer from eating disorders for a lifetime. On another hand, the effective treatment options are still inconclusive. Psychotherapy, especially and cognitive behavior, is one of the most effective treatments at present.

On the other hand, psychotherapy is quite expensive, requiring not only a large number of qualified therapists, but also a long treatment time. Which leads to a high treatment cost. In order to reduce the cost of treatment, group therapy is a reasonable choice. However, currently there are no related research reports in china.

Our study is to examine whether the G-CBT for anorexia nervosa is effective or not. The study will use randomized controlled study design. 80 patients with AN will be recruited from Shanghai Mental Health Center, There will be two groups: CBT treatment group and conventional treatment group. Each group is 40 and then the CBT group will be given standard CBT intervention for 12 weeks. The control group will receive outpatient treatment. To assess the eating disorder symptoms, impulsive and emotional change, clinical symptom scales, psychological scales and the security indexs will be used at baseline, 4 weeks, 8 weeks, 12 weeks (end of treatment), 24 weeks (3 months after treatment) and 36 weeks (6 months after treatment follow-up).

This study was designed with sufficient consideration about innovation as well as feasibility, and is to be operated on well proved theoretical basis and guidance of an operation manual. If successful, results of this study may bring great improvement to clinical practice of this refractory mental disorder. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03684239
Study type Interventional
Source Shanghai Mental Health Center
Contact Jue Chen, PHD
Phone 8618017311203
Email chenjue2088@163.com
Status Recruiting
Phase N/A
Start date March 1, 2018
Completion date December 31, 2020

See also
  Status Clinical Trial Phase
Completed NCT03247946 - The Influence of Upright Feeding Position on Pulmonary and Ear Morbidity N/A
Completed NCT03202576 - Nasogastric Tube Securement Comparison Study N/A
Recruiting NCT05587127 - Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia N/A
Completed NCT03211468 - Intervention Program to Improve Body Image and Self-Esteem Among Female Athletes. N/A
Completed NCT03759444 - Perception of Time by Individuals With Eating Disorders
Recruiting NCT06256380 - Comparing Enhanced Cognitive-behavior Therapy and Family-based Treatment for Adolescents With an Eating Disorder N/A
Active, not recruiting NCT03808467 - Cognitive Training for Patients With Eating Disorders N/A
Completed NCT04431284 - Impact of COVID-19 Lockdown on Obesity and Eating Behaviors
Active, not recruiting NCT03987984 - Reliability and Validity of the Turkish Version of the Sensory Eating Problems Scale
Completed NCT03455088 - The Effect of G-DBT on the Patients With BN : A Multicenter Randomized Controlled Study N/A
Not yet recruiting NCT06057415 - Improving Gastrointestinal Function In High-Risk Newborns By Stimulation Of The Enteric Nervous System N/A
Not yet recruiting NCT05873127 - Web-based Guided Self-help CBT-E vs Online G-CBT-E for Binge Eating Behavior N/A
Completed NCT03490786 - A Dose Escalating Study to Assess the Safety and Tolerability of GT-001 Phase 1
Completed NCT03375853 - Computerized Response Training Obesity Treatment N/A
Completed NCT05053438 - Evaluating Hunger Manipulation During Feeding Intervention N/A
Recruiting NCT05186441 - The Effect of iTBS on the Inhibition Control Function of BN N/A
Active, not recruiting NCT03968705 - Longstanding Eating Disorders and Personality Disorders
Recruiting NCT05038033 - Addressing Anxiety and Stress for Healthier Eating in Teens N/A
Not yet recruiting NCT06266507 - Examining the Effect of Occupational Therapy-Based Parent Coaching on Feeding Problems in Children With a Preterm Birth N/A
Terminated NCT04837989 - Effectiveness of the Diabetes Body Project Among Females With Type 1 Diabetes N/A