FMT for Steroid Resistant Gut Acute GVHD

Status Recruiting

Clinical Trial Summary

The study aims to evaluate the safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of steroid resistant graft-versus-host-disease (GVHD) of the gut. This strategy might offer a safe and effective therapeutic approach for these patients with a poor prognosis and limited therapeutic options.

Clinical Trial Description

Graft-versus-host-disease (GVHD) is a major complication after hematopoietic stem cell transplantation (HSCT). Gut is the most vulnerable target organ of acute GVHD. Patients who develope the acute gut GVHD and do not respond to the first line therapy with steroids have a high mortality. The investigation of safe and effective second line therapy for these patients are in need. The study evaluates safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of streoid resistant GVHD of the gut. Stool for FMT will be prepared from the healthy donor.This strategy might offer a safe and effective therapeutic approach for these acute steroid resistant gut GVHD patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04285424
Study type	Interventional
Source	Affiliated Hospital to Academy of Military Medical Sciences
Contact	Min Min, MD
Phone	13426165452
Email	minmin823@sina.com
Status	Recruiting
Phase	Early Phase 1
Start date	March 1, 2020
Completion date	March 1, 2022

View Details

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