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Fatty Liver clinical trials

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NCT ID: NCT01758770 Completed - Obesity Clinical Trials

China Action on Spine and Hip Status

CASH
Start date: October 2012
Phase: N/A
Study type: Observational

1. To determine the prevalences of osteoporotic fracture in elderly Chinese population. 2. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement. 3. To investigate the difference in the prevalences of osteoporosis between cities and urban-rural area in China. 4. To investigate the association of body composition with osteoporosis 5. To investigate the prevalence of liver steatosis in China 6. To investigate the application of QCT fat measurement

NCT ID: NCT01754714 Completed - Clinical trials for Non Alcoholic Fatty Liver Disease

Study to Investigate the Effects of Different Doses of S-adenosyl-L-methionine (SAMe) in Subjects With Nonalcoholic Fatty Liver Disease and Non-treated Matched Healthy Volunteers as Control Group

EXPO
Start date: December 2012
Phase: Phase 3
Study type: Interventional

Investigation the Effects of Different Doses of SAMe in Subjects with Nonalcoholic Fatty Liver Disease and non-treated matched healthy volunteers as control group

NCT ID: NCT01747772 Recruiting - Clinical trials for Non-Alcoholic Fatty Liver Disease

Sonoelastography: Ultrasound Method to Measure Liver Fibrosis

Start date: February 2010
Phase: N/A
Study type: Interventional

HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) provide accurate quantitative measurements that can be used to stage liver fibrosis in patients with chronic liver disease. 1. To measure liver stiffness with sonoelastography in adults with suspect diffuse liver disease who will undergo nonfocal liver biopsy as part of their routine clinical care. 2. To assess the sensitivity and specificity of sonoelastography for the detection and staging of liver fibrosis

NCT ID: NCT01735799 Not yet recruiting - Clinical trials for Nonalcoholic Fatty Liver Disease

THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS

Start date: November 2012
Phase: N/A
Study type: Observational

Since both pathologies (PCOS and NAFLD) involve disturbed carbohydrate economy, which revolve around insulin resistance, it is tempting to examine the specific "liver profile" of women with PCOD. Furthermore, it would be of great importance if lean women who suffer from PCOD would be revealed to shere cardiovascular risks with their more overweight peers. Patients - women who will be diagnosed with PCOD following their initial referal to our fertility clinic. Controls - normal ovulatory women who approached our fertility clinic due to either unexplained or male factor infertility. Workup - history for menstrual pattern; Clinical evaluation for features of hyperandrogenism; ultrasonographic documentation of ovarian morphology; follicular phase hormonal profile for validation of the diagnosis and for ruling out other pathologies which may cause anovulation. Liver profiling - The following blood tests will be used for the biochemical profiling: fasting glucose and insulin, CRP, HDL-cholesterol, triglycerides, AST, ALT, GGT, LDH, alkaline phosphatase, total bilirubin, direct bilirubin, ferritin, HBA1C and micro albumin ratio. FibroScan® will be used to measure liver stiffness.

NCT ID: NCT01725035 Completed - Fatty Liver Clinical Trials

Hepatic De Novo Lipogenesis (DNL)in the Pathogenesis of Hepatic Steatosis in Obese Youth

DNL
Start date: December 2010
Phase:
Study type: Observational

Nonalcoholic Fatty Liver Disease (NAFLD) is becoming the most common cause of liver disease in pediatrics, but little is known about its pathophysiology in children. While studies in obese adults with hepatic steatosis have described an increased hepatic de novo lipogenesis (DNL) depending on the diet, there are no studies exploring the mechanisms by which excess hepatic triglycerides increases in obese youths, thus explaining the accompanying dyslipidemia and the metabolic syndrome. The central hypothesis of this study is that hepatic conversion of carbohydrates to lipid (DNL) is enhanced and associated with accumulation of excess liver fat, dyslipidemia and hepatic insulin resistance in obese youths with hepatic steatosis. The overall goal is to examine whether hepatic DNL is increased in obese youths with steatosis compared to matched controls without steatosis. Hypotheses: Hepatic conversion of carbohydrates to lipid (DNL) is enhanced and is associated with accumulation of excess liver fat, dyslipidemia and hepatic insulin resistance in obese youths with hepatic steatosis.

NCT ID: NCT01720719 Recruiting - Diabetes Mellitus Clinical Trials

Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease

Start date: May 2013
Phase: Phase 4
Study type: Interventional

The purpose of the study is to compare the impact of atorvastatin 20mg qd and Vitamin E 300mg qd therapy on liver fat content in patients with type 2 diabetes associated with high LDL-C and non-alcoholic fatty liver disease.

NCT ID: NCT01712711 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

Helicobacter Pylori Eradication in Diabetic Subjects With Non-alcoholic Fatty Liver Disease

Start date: September 2012
Phase: Phase 2
Study type: Interventional

The aim of study was to evaluate the effect of helicobacter pylori eradication on liver fat content, liver function tests, lipid profile, homeostasis model assessment-IR (HOMA-IR) index, and anthropometric measurements (body mass index and waist circumference)in diabetic subjects with non-alcoholic fatty liver disease.

NCT ID: NCT01707914 Completed - Clinical trials for Nonalcoholic Fatty Liver Disease

Clinical Investigation on the Effects of Bayberry Juice Treatment in Adult Subjects With Features of Fatty Liver Disease

Start date: June 2012
Phase: N/A
Study type: Interventional

Chinese bayberry, one of six Myrica species native to China, is rich in anthocyanins, and cyanidin-3-O-glucoside (C3G) was identified as a major anthocyanin component. In previous animal studies from us and other investigators, anthocyanins have been shown to ameliorate dyslipidemia and hepatic steatosis in different rodent models. The aim of the present study was to examine the effects of Chinese bayberry juice (CBJ) on the serum lipid profile and on levels of biomarkers related to antioxidant status in young adults with features of fatty liver disease.

NCT ID: NCT01705522 Recruiting - Ulcerative Colitis Clinical Trials

Multimodal Approach in IBD Patients

MAID
Start date: October 2012
Phase:
Study type: Observational

The investigators intend to assess the role of several biomarkers in the prediction of relapse in IBD. Clinical, laboratory and endoscopic data will be gathered and a predictive score will be derived in order to assess the relapse risk at 1 year.

NCT ID: NCT01703260 Terminated - Clinical trials for Nonalcoholic Steatohapatitis

Safety and Efficacy of Roflumilast and Pioglitazone in Treating Adults With Nonalcoholic SteatoHepatitis

Start date: June 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effect of roflumilast and pioglitazone therapy on serum transaminase (ALT) levels in adults with Nonalcoholic SteatoHepatitis.