Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway

Status Not yet recruiting

Clinical Trial Summary

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing coronavirus disease, Covid-19, has spread rapidly across the globe since its emergence in January 2020. As of January 2021, there are 87.6 million confirmed cases worldwide, with 1.9milion deaths. In conjunction with this high disease incidence, there have also been reports of Covid-19 related sleep disordered breathing, with up 18% in a Chinese study and 57% in an Italian study of individuals with Covid-19 reporting sleep disturbance. Obstructive Sleep Apnea (OSA) is a common, chronic condition due to partial or complete upper airway collapse during sleep. OSA is more common in males & obese individuals, both of which are more adversely affected by SARS-CoV-2 infection. Furthermore, inflammation of the upper airway, or nasal passages leading to congestion could lead to a compromised upper airway during sleep and subsequently, obstructive sleep apnea. We believe that's SARS -CoV-2 infection, and subsequent Covid-19 will lead to an altered microbiome in the upper airway. This is turn will lead to worsening nasal inflammation and congestion, which could predispose individual with previous Covid-19 disease to OSA. Additionally, OSA is treated with Continuous Positive Airway Pressure (CPAP) a machine which delivers pressurized air into the upper airway via a face mask. This keeps the upper airway open during sleep. When CPAP is well tolerated by individuals, it works well to reduce the symptoms of OSA. Unfortunately, many patients find it difficult to tolerate CPAP. One reason often reported for poor tolerance is nasal congestion. We believe that an altered upper airway microbiome, due to previous SARS-CoV-2 infection, will affect treatment adherence to CPAP therapy. Secondly, we will investigate if treatment with CPAP therapy causes any change in the upper airway microbiome.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05116657
Study type	Observational
Source	Royal College of Surgeons, Ireland
Contact
Status	Not yet recruiting
Phase
Start date	November 22, 2021
Completion date	January 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04979858` - Reducing Spread of COVID-19 in a University Community Setting: Role of a Low-Cost Reusable Form-Fitting Fabric Mask	N/A
Recruiting	`NCT05311410` - Viral Kinetics of SARS-CoV-2 in Patients With COVID-19 in the Intensive Care Unit Undergoing Dental Procedures	N/A
Active, not recruiting	`NCT05073718` - SARS-CoV-2 and Acetylsalicylic Acid (SARA)	Phase 3
Completed	`NCT05055492` - The School SPIT Study - Elementary Schools in High COVID-19 Incidence Regions	N/A
Completed	`NCT05060510` - The School SPIT Study - COVID-19 Testing in Secondary Schools	N/A
Completed	`NCT05055505` - The School SPIT Study - Elementary Schools in Low COVID-19 Incidence Regions	N/A
Completed	`NCT05054218` - COVID-19 Immunogenicity of a Third Dose of mRNA-1273 Vaccine Among Cancer Patients
Completed	`NCT05449392` - Topical Antibacterial Agents for Prevention of COVID-19	Phase 1
Completed	`NCT05076253` - Efficacy of Ivermectin in COVID-19	Phase 1/Phase 2
Recruiting	`NCT05172024` - Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
Terminated	`NCT05593770` - International Sites: Novel Experimental COVID-19 Therapies Affecting Host Response	Phase 2/Phase 3
Completed	`NCT05030974` - RECOVAC Repeated Vaccination Study	Phase 4
Withdrawn	`NCT05067946` - Evaluation of Efficacy, Safety and Immunogenicity of GX-19N in Healthy Individuals Who Have Received COVID-19 Vaccines	Phase 2/Phase 3
Not yet recruiting	`NCT05013034` - Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult Patients	Phase 2
Withdrawn	`NCT05393999` - SABRE: A Single-arm Prospective Study Measuring Safety and Tolerability of SARS-CoV-2 Neutralising Antibodies in High-risk Populations	Phase 2
Recruiting	`NCT05047783` - Masitinib in Patients With Symptomatic Mild to Moderate COVID-19	Phase 2
Recruiting	`NCT04590222` - Impact of a Monoamine Oxidase Inhibitor on the Phenotype of Blood Mononucleated Cells in Patients With COVID-19
Completed	`NCT04551911` - Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19	Phase 2
Completed	`NCT04953039` - Use of Saliva for COVID-19 Diagnosis
Active, not recruiting	`NCT06181292` - Safety and Immunogenicity of a Booster Vaccination With an Adapted Vaccine	Phase 2/Phase 3

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway Microbiome

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms