Fibromyalgia Clinical Trial
Official title:
Unraveling Impaired Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes: a Series of Experiments Targeting Brain Neurotransmission
Both patients with peripheral structural pathologies, like rheumatoid arthritis
(RA)-patients, or patients with central sensitivity syndromes (CSS) suffer chronic pain. CSS
are characterized by an increased responsiveness of central pain neurons. An impaired
endogenous pain inhibition is already demonstrated in CSS. In the present study the
investigators want to evaluate the efficacy of pain inhibition in response to physical
stressors and whether the efficacy is opioid-mediated in two chronic pain populations (RA &
CCS) compared to controls.
Therefore a triple-blinded randomized controlled trial (RCT) with cross-over design will be
performed. The efficacy of wind-up of pain and spatial summation of pain is evaluated before
and after a submaximal exercise, while the experimental group receives a selective serotonin
reuptake inhibitor. Participants are 20 RA-patients and 20 CSS-patients, more specific
patients with fibromyalgia and chronic fatigue syndrome, and 30 healthy controls. This way,
the investigators analyze how pain inhibition reacts on different types of physical
stressors in different pain patients and if pain inhibition is opioid-mediated.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
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