Familial Frontotemporal Dementia Clinical Trial
Official title:
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.
This multicenter study will enroll 300 members of familial Frontotemporal Dementia (FTD)
families across 8 experienced FTD research centers with a known mutation in MAPT, PGRN, or
C9ORF72 (100 mutation carriers with mild dementia or minimally symptomatic yet non-demented,
100 asymptomatic mutation carriers, and 100 clinically normal relatives who are non-mutation
carriers) to obtain annual assessments including T1-MRI, FLAIR, diffusion tensor imaging
(DTI), ASL perfusion (ASLp), intrinsic connectivity functional MRI (icfMRI), MR spectroscopy
(MRS), CSF, blood, and behavioral, neuropsychological and functional assessment, for a total
of three assessments per participant.
A primary goal of this study is to identify the most robust and reliable methods to track
disease progression in familial FTD so that disease-modifying therapeutic trials can be
designed appropriately.
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