Fallopian Tube Cancer Clinical Trial
Official title:
A Pilot Study of Acute Normovolemic Hemodilution in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer
The purpose of this study is to help us learn how to lower the risk of a blood transfusion
during surgery to remove ovarian cancer. Acute normovolemic hemodilution (ANH) is a technique
performed in the operating room before the procedure begins that may reduce the risk of
needing a transfusion during ovarian cancer surgery. During surgery, the patient's own blood
is given back to them when needed, usually due to bleeding. If you don't need blood during
surgery, your own blood will be given back at the end of the case.
The idea behind ANH is that that by removing the blood and replacing it with other fluids,
the remaining blood becomes diluted. This diluted blood is then lost during surgery, usually
due to bleeding. The original non-diluted blood is then transfused back as needed. This may
mean a lower chance of needing an additional blood transfusion.
ANH has been studied at this hospital for other types of cancer. These studies suggest that
ANH may help conserve blood. Although most studies suggest that ANH can be performed safely,
one study showed that ANH could be associated with a higher rate of serious bowel
complications than standard treatment. In this study, patients who underwent ANH had a higher
rate of anastomotic leaks during bowel surgery. An anastomotic leak occurs when two ends of
bowel that have been cut and sewn back together (the anastomosis), fall apart. The
investigators don't know whether ANH will result in higher rates of anastomotic leaks in
patients having ovarian cancer surgery. In fact, in another study evaluating ANH in patients
having the kind of bowel resections that often occur in ovarian cancer surgery (the colon),
no increased risk of anastomotic leaks was observed. For these reasons, researchers at MSKCC
are conducting a study to find out if ANH can be used safely in patients undergoing surgery
for ovarian cancer.
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