Fall Clinical Trial
Official title:
Association Between Antidepressant Use and Falls in Older Adults: Analysis of the World Health Organization Global Database
The incidence of fall in older adults aged 65 and over is estimated at 30%, and 50% of the people aged 80 and over with at least one fall a year. Falls are associated with significant morbidity and mortality. The origin falls is often multifactorial, involving intrinsic and extrinsic factors. Few studies have investigated the association with all antidepressants. Potential adverse effects of antidepressants such as hyponatremia, sedation, orthostatic hypotension, extrapyramidal symptoms are known risk factors for falls. Due to multimorbidity, polypharmacy including interaction risks, and aging-related changes in pharmacokinetic and pharmacodynamic of drugs, antidepressants may further increase this risk in older patients. Based on the World Health Organization global database, the main objective of this study is to investigate the association between antidepressants classes and the occurrence of falls reported in the database. A disproportionality analysis will be performed. It will aim to assess whether some classes of antidepressants, and within these classes some molecules, are associated with a greater risk of falls. A mediation analysis will also be performed. It will aim to examine some of the mediators involved in the association between antidepressants classes and falls.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04612842 -
Engaging Older Adults in Fall Prevention Using Motivational Interviewing (MI)
|
N/A | |
| Enrolling by invitation |
NCT03297632 -
Improving Muscle Strength, Mass and Physical Function in Older Adults
|
N/A | |
| Completed |
NCT06063187 -
Technology-based Fall Risk Assessments for Older Adults in Low-income Settings
|
||
| Withdrawn |
NCT04470895 -
Impact of Drugs on the Risk of Falls in the Fracture Department of the Paris Saint-Joseph Hospital Group
|
||
| Recruiting |
NCT05940779 -
Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Conditions in the Elderly: a Randomized Crossover Clinical Trial.
|
N/A | |
| Not yet recruiting |
NCT05940636 -
A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
|
N/A | |
| Not yet recruiting |
NCT05991037 -
Relation Between Psychoactive Drugs Overdosage and Severity of Falls in Elderly People
|
N/A | |
| Completed |
NCT03566719 -
Effect of an Exercise Program on Risk of Fall in a Community Dwelling Older Adults
|
N/A | |
| Not yet recruiting |
NCT05702801 -
Vibratory Stimulation to Improve Balance Recovery
|
N/A | |
| Not yet recruiting |
NCT04439097 -
Effects of Multicomponent Physical Exercise Program and Mediterranean Diet in Alzheimer's Disease
|
N/A | |
| Recruiting |
NCT04108741 -
Augmented Reality Treadmill Training in Patients With Parkinson's Disease
|
N/A | |
| Completed |
NCT04760392 -
Goal-directed Mobilization of Medical Inpatients
|
N/A | |
| Not yet recruiting |
NCT03680014 -
Remote Monitoring and Analysis of Gait and Falls Within an Elderly Population
|
||
| Recruiting |
NCT04851405 -
Implementing an Evidence-based Exercise Program to Reduce Falls in Community-dwelling Older Adults (Otago)
|
N/A | |
| Completed |
NCT05090774 -
Integrating Fall Prevention Balance Exercises Into a Program for Older Adults With Peripheral Artery Disease (PAD): A Mixed Methods Feasibility Study
|
N/A | |
| Completed |
NCT04334746 -
The Discriminative Ability of the Four Balance Measures for Fall History
|
||
| Completed |
NCT03341728 -
The Sensorimotor Locus of Balance Control in Elderly Gait
|
N/A | |
| Completed |
NCT05290571 -
Modified Otago Exercise Program on Balance Performance
|
N/A | |
| Completed |
NCT04622657 -
Validity Reliability of The Dubousset Functional Test in Parkinson Disease
|
N/A | |
| Completed |
NCT05863143 -
Intervention on Reducing Risk of Falls Among Community Dwelling Older Adults in Selangor
|
N/A |