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Facet Joint Pain clinical trials

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NCT ID: NCT06236308 Not yet recruiting - Facet Joint Pain Clinical Trials

TTAX03 for the Treatment of Lumbosacral Facet Joint Pain

Start date: July 15, 2024
Phase: Phase 1
Study type: Interventional

This is a pilot study examining the safety and efficacy of a single intra-articular (IA) injection of TTAX03 per joint to relieve severe spinal facet joint (FJ) pain and improve function in subjects with facet joint pain (FJP) in the lumbosacral region. The design is randomized, double blinded, placebo controlled and dose-group sequential.

NCT ID: NCT06157294 Completed - Pain, Chronic Clinical Trials

Pulsed Radiofrequency Treatment in Lumbar Facet-Related Pain

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

Facet joint-related pain is one of the leading causes of low back pain. Facet joint-related disorders can have a negative impact on quality of life and daily living activities, in addition to the pain.Conservative treatment methods such as analgesic medications, physical therapy, and manual therapy are used for facet joint-related low back pain, and interventional pain management practices are used in patients who do not respond adequately to these treatments. Pulse radiofrequency application, which is a recent popular treatment in interventional pain management, is also frequently applied in the treatment of facet-joint related pain. Pulsed radiofrequency intervention can be applied directly intra-articularly or can be applied to the median branch, which is important structure in pain transmission. Although both methods are frequently used in pain management, there is a lack of information in the literature about which is more effective. This study aimed to compare the treatment results of intraarticular pulse radiofrequency application and median branch pulse radiofrequency application in facet joint-related low back pain.

NCT ID: NCT06016127 Completed - Low Back Pain Clinical Trials

Cryoneurolysis for Facet Mediated Chronic Low Back Pain

Start date: June 18, 2022
Phase: N/A
Study type: Interventional

This is a single-center, randomized, pilot study in adult subjects with facet mediated CLBP. Thirty (30) subjects are planned for initial enrollment and will be randomized 1:1 to receive ioveraº medial branch cryoneurolysis or radiofrequency ablation.

NCT ID: NCT05961800 Recruiting - Analgesia Clinical Trials

Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

OMEGA
Start date: July 5, 2023
Phase: N/A
Study type: Interventional

This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).

NCT ID: NCT05952518 Not yet recruiting - Facet Joint Pain Clinical Trials

PNS vs RFA for Facet Joint Pain

Start date: October 2023
Phase: N/A
Study type: Interventional

Radiofrequency ablation of the medial nerve is the current surgical treatment for back pain originating from the facet joints in the spine. However, this procedure causes denervation of spinal muscles. Peripheral nerve stimulation is another treatment for facet joint pain that may not cause damage to the spinal muscles. This study will compare both treatments in terms pain relief and spine biomechanics.

NCT ID: NCT05949970 Recruiting - Facet Joint Pain Clinical Trials

The Lumbar Trident Study

Start date: July 1, 2023
Phase:
Study type: Observational

This observational retrospective study evaluates the efficacy of RF with the three-tined expandable electrode needle compared to before treatment in the treatment of chronic lumbar facet joint pain.

NCT ID: NCT05931653 Recruiting - Facet Joint Pain Clinical Trials

Multimodal PT With and Without Proprioceptive Training in Lumber FJS

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

This will be a randomized clinical trial. The study will be conducted at Pakistan Railways General Hospital Rawalpindi and Riphah International Hospital Islamabad. Patients with FJS will be included. The aim of this study is to find the comparative effects of multimodal physical therapy treatment and proprioceptive training along with multimodal physical therapy treatment on pain, lumbar ranges of motion, disability, fatigue, lumbar lordosis curvature and balance. Participants will be assessed for pain, lumbar range of motions, lumbar lordosis, disability, fatigue and balance before treatment. The intervention duration is 06 weeks, 03 sessions per week will be given to all participants. Pain and lumbar ranges of motion will be measured on every visit. At the end of 06th week final readings for functional status, fatigue level, lumbar lordosis angle, fall risk and limits of stability will also be recorded. Data will be analyzed by SPSS v.23.

NCT ID: NCT05909709 Recruiting - Back Pain Clinical Trials

Dose Escalation Pilot Study to Evaluate the Safety of Alocyte for the Treatment of Facetogenic Back Pain

Start date: April 29, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see if the use of Alocyte (cord blood plasma plus mononucleic cells) will be safe, well tolerated, and whether it causes any side effects. The study will also examine if the use of the Investigational Product (IP) is able to reduce local inflammation or alleviate Facetogenic back pain

NCT ID: NCT05353465 Completed - Facet Joint Pain Clinical Trials

The Cervical Trident Study

Start date: May 20, 2022
Phase:
Study type: Observational

This observational retrospective study evaluates the efficacy of RF with the three-tined expandable electrode needle compared to before treatment in the treatment of chronic cervical facet joint pain.

NCT ID: NCT05196919 Completed - Inflammation Clinical Trials

Safety and Efficacy of XT-150 for Facet Joint Osteoarthritis Pain

Start date: February 24, 2022
Phase: Phase 2
Study type: Interventional

This is a Phase 2a safety and efficacy study of XT-150 in adult participants experiencing back pain due to inflammation of the facet joint, also known as facet joint osteoarthritis (FJOA), and who are eligible for intra articular glucocorticoid injection, or radiofrequency ablation of medial branches of the primary dorsal ramus of the exiting nerve root, which innervates the adjacent facet joints. Study drug will be administered at Day 0 and Day 90 by bilateral intra-articular (IA) injection into the facet capsule, at the affected spinal level (e.g. Lumbar [L]3-4, L4-5, or L5-Sacrum [S]1) as determined by imaging (e.g., Magnetic resonance imaging [MRI], Computed tomography [CT]), X-ray, etc.) and physical exam. Up to 72 participants will be randomized to placebo or one of two dose treatment groups (24 participants per treatment group). 1. 0.15 mg XT-150 (1.0 milliliter [mL] total delivered by two 0.5 mL injections) 2. 0.45 mg XT-150 (1.0 mL total delivered by two 0.5 mL injections) 3. Placebo (Sterile saline) (1.0 mL total delivered by two 0.5 mL injections)