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Eye Diseases clinical trials

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NCT ID: NCT05723770 Completed - Clinical trials for Dry Eye Disease (DED)

Effects of NOV03 on the Tear Film

Start date: August 14, 2023
Phase: Phase 4
Study type: Interventional

Determine the effect of a single instillation of NOV03 on the thickness and evaporation rate of the mucus-aqueous layer of the tear film

NCT ID: NCT05717543 Completed - Eye Diseases Clinical Trials

Imaging of Corneal and Crystalline by Near Infrared Retro-illumination

RETRO-ILLUMI
Start date: January 26, 2023
Phase: N/A
Study type: Interventional

Retroillumination photography is difficult. The reflections on the cornea and the lens are constant and prevent from obtaining a complete and clear image. Study team have modified a slit lamp intended to photograph the anterior segment of the eye in retroillumination by using a light source in the near infrared (780 nm), and a process which eliminates the reflections.

NCT ID: NCT05700422 Completed - Dry Eye Clinical Trials

Nasal Spray Study in Sjogren's Dry Eye Disease

Start date: May 1, 2023
Phase: Phase 4
Study type: Interventional

This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and symptoms of dry eye disease in those Sjogren's Syndrome. Patients at least 18 years old with moderate-to-severe Sjogren's dry eye disease may be eligible for this study. If you are eligible to participate in the study and you decide to join, there will be 3 study visits over approximately 1 month. You will also self-administer the nasal spray at home every day, 2 times a day during this month.

NCT ID: NCT05686421 Completed - Glaucoma Clinical Trials

Comfortable and Stabilizing Chin & Forehead Rest Attachment for Slit Lamp Configurations

Start date: March 30, 2023
Phase: N/A
Study type: Interventional

In this study, participants will be imaged using two Optical Coherence Tomography (OCT) devices: device N, a standard conventional OCT device with an invention (comfortable chin and forehead rest that can be adjusted to fit each individual's size) attached to the device; and device C, the standard conventional OCT device with no invention attached. The investigators will assess whether the chin and forehead rest attachment (invention) provides a more comfortable experience for patients.

NCT ID: NCT05671120 Completed - Eye Diseases Clinical Trials

Transcutaneous Levator Recession for Non-thyroid Lid Retraction

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This work aims to describe and assess the efficacy of transcutaneous levator palpebrea superioris muscle recession as a surgical procedure for treatment of upper lid retraction of various causes other than thyroid eye disease

NCT ID: NCT05660681 Completed - Dry Eye Disease Clinical Trials

Evaluation of the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops

Start date: December 12, 2022
Phase: N/A
Study type: Interventional

The primary objective is to evaluate the tolerability and efficacy of CWT-f-002 lubricant eye drops in the treatment of the signs and symptoms of dry eye disease.

NCT ID: NCT05656027 Completed - Presbyopia Clinical Trials

Phase 3 Evaluation of the Safety and Efficacy of LNZ101 for the Treatment of Presbyopia

CLARITY
Start date: December 19, 2022
Phase: Phase 3
Study type: Interventional

Phase 3 study to evaluate the safety and effectiveness of LNZ101 for the treatment of Presbyopia.

NCT ID: NCT05613517 Completed - No Eye Disorder Clinical Trials

Study of the Angle Lambda and Ocular Dominance

EPOLAF
Start date: November 25, 2022
Phase:
Study type: Observational

Anatomical ophthalmological connections and their dynamics are still debated in the scientific community. However, their considering is essential in many surgeries (strabismus, cataract, refractive...) or in clinical practice. The correlation between these biometric values would make it possible to refine the knowledge related to these landmarks and thus offer better ophthalmological management by integrating these variables into the clinical examination. The aim of the study is to analyze the correlation between the angle lambda and the ocular dominance depth in healthy individuals without ophthalmologic disorder. Then, seconds goals were defined as the study of the relation between the value of the angle lambda and the fixation disparity quantified with the Rousseau test. Relation between ocular dominance measured with the Guillon's test and the Hole-in-car test will also studied.

NCT ID: NCT05604651 Completed - Dry Eye Disease Clinical Trials

Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease

Start date: March 1, 2021
Phase:
Study type: Observational

The study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including MUC1, MUC4, MUC16 and MUC20, are altered in conjunctival cells of visual display users With and Without Dry Eye Disease, and 2) if mucin levels correlate with dry eye clinical diagnostic data.

NCT ID: NCT05586152 Completed - Dry Eye Disease Clinical Trials

Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease

Start date: August 30, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

Phase 1/2, first-in-human, 2-part study to assess topically administered eyedrops of INV-102 during 2-week repeat dosing in subjects with moderate symptomatic dry eye disease. Part 1 will be a Dose Escalation phase across 4 cohorts of subjects to assess safety and tolerability of INV-102, and Part 2 will be an Optional Dose Expansion phase in a fifth cohort of subjects, pending the outcome of Part 1, to assess efficacy of INV-102 in the treatment of moderate symptomatic dry eye disease.