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Eye Diseases clinical trials

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NCT ID: NCT05768152 Not yet recruiting - Eye Diseases Clinical Trials

Repeated Low-Level Red-Light Therapy Shortens Axial Length

Start date: March 2023
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to investigate the incidence and magnitude of axial length shortening after repeated low-level red-light therapy in high myopia children and teenagers.

NCT ID: NCT05738629 Not yet recruiting - Dry Eye Disease Clinical Trials

Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm

Start date: March 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the preliminary safety and effectiveness of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops in the treatment of dry eye diseases post refractive surgery and associated with blepharospasm

NCT ID: NCT05724056 Not yet recruiting - Dry Eye Disease Clinical Trials

Idroflog® for Treatment of Dry Eye Disease (IDROFLOG)

IDROFLOG
Start date: March 1, 2023
Phase: N/A
Study type: Interventional

This study aims at demonstrating the non-inferiority of Idroflog compared to sodium hyaluronate 0.18% for the disease improvement of people with documented history of dry eyes and use of tear substitutes for at least 3 months.

NCT ID: NCT05565547 Not yet recruiting - Eye Diseases Clinical Trials

Multimodal Equipment for Teleophthalmology Assessment (META)

Start date: October 15, 2022
Phase:
Study type: Observational

We have developed a Multimodal Equipment for Teleophthalmology Assessment (META) device. This novel device is compact, portable and suitable for packaging and express delivery. With this device, there is a potential to implement a new concept of "hospital-at-home" eye care model. The present study is designed to validate the META device for future clinical usage and investigation. We will compare the performance of the META device with those provided by commercial devices in terms of image quality of optical coherence tomography (OCT), anterior segment and fundus camera, and evaluate the level of agreement in lesion detection and quantitative measurements between META and other commercial devices (e.g., Heidelberg Spectralis OCT, Haag-Streit BQ900 Slit-lamp imaging, Canon CR-2 fundus imaging, Zeiss IOL Master 500).

NCT ID: NCT05550740 Not yet recruiting - Eye Diseases Clinical Trials

Repeated Low-Level Red-Light Therapy for Shortening Axial Length

Start date: October 22, 2022
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to confirm the incidence and magnitude of axial length shortening after RLRL therapy in Chinese high myopia children and teenagers.

NCT ID: NCT05532072 Not yet recruiting - Clinical trials for Graves Ophthalmopathy

Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.

Start date: September 2022
Phase: Early Phase 1
Study type: Interventional

This study is a randomized, controlled, multi-center clinical study, the purpose is to evaluate the efficacy and safety of rapamycin combined with methylprednisolone in the treatment of moderate to severe active GO. GO patients with moderate to severe activity were selected as the research objects, and the screening period was 1 week. Eligible and well-informed subjects were randomly assigned 1:1 to the experimental group (rapamycin + methylprednisolone) or the control group (methylprednisolone group). The control group was given methylprednisolone pulse 500 mg/time once a week for 6 weeks + 250 mg/time once a week for 6 weeks, and the experimental group was given rapamycin 2 mg/day orally for 24 weeks on the basis of methylprednisolone pulse therapy. The follow-up period was from 25th to 36th week. Before treatment, 1 week after treatment, 6 weeks, 12 weeks, 24 weeks, and 36 weeks, visits were conducted to evaluate the improvement and safety evaluation of patients' GO eye activity, severity, and quality of life. At the end of the 1st week and the 12th week, the blood concentration of rapamycin was measured.

NCT ID: NCT05309811 Not yet recruiting - Eye Diseases Clinical Trials

Effect of Repeated Low-Level Red-Light Therapy on Visual Field Damage in Primary Open-angle Glaucoma

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effect of repeated low-level red-light therapy on existing visual field damages in primary open-angle glaucoma patients.

NCT ID: NCT05247099 Not yet recruiting - Children Clinical Trials

Pediatric Eye Care Investigated Team

PECT
Start date: February 2022
Phase:
Study type: Observational

Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.

NCT ID: NCT05136924 Not yet recruiting - Dry Eye Disease Clinical Trials

IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL

Start date: December 1, 2021
Phase: Phase 2
Study type: Interventional

A Randomized, Controlled, Double-Masked, Two-Arm Investigator-Initiated study to Assess the Efficacy of OC-01 (varenicline) Nasal Spray on signs and symptoms of Dry Eye Disease in subjects following Corneal Collagen Crosslinking (CXL)

NCT ID: NCT04970329 Not yet recruiting - Dry Eye Disease Clinical Trials

Corneal Thickness Changes in Patient Undergoing Dry Eye Managment

Start date: July 2021
Phase: N/A
Study type: Interventional

The purpose of this research is to the determine effect of dry eye and to compare the effect of artificial tears on central and peripheral corneal thickness.