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Eye Diseases clinical trials

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NCT ID: NCT05941182 Not yet recruiting - Clinical trials for Ophthalmic Disorders

Co-designing and Evaluating a Real-world Implementation Model for Remote Consultation With Vision Self-testing.

ReVise
Start date: September 3, 2023
Phase:
Study type: Observational

This study aims to involve the public, patients and National Health Service (NHS) staff in co-designing a scalable, inclusive and sustainable implementation model for ophthalmic remote consultation with vision self-testing (the intervention). The main study questions are: What are the barriers to uptake of the intervention and how can these be mitigated by the design of the implementation model. How do implementation outcome measures compare before and after real world application of the model.

NCT ID: NCT05936489 Completed - Presbyopia Clinical Trials

Plasma Pharmacokinetics and Safety of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Subjects With Presbyopia

Start date: July 6, 2023
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label, randomized study to assess the plasma pharmacokinetic profile of LNZ101 and LNZ100.

NCT ID: NCT05930444 Completed - Eye Diseases Clinical Trials

Multimodal Machine Learning for Auxiliary Diagnosis of Eye Diseases

Start date: July 21, 2023
Phase:
Study type: Observational

With rapid advancements in natural language processing and image processing, there is a growing potential for intelligent diagnosis utilizing chatGPT trained through high-quality ophthalmic consultation. Furthermore, by incorporating patient selfies, eye examination photos, and other image analysis techniques, the diagnostic capabilities can be further enhanced. The multi-center study aims to develop an auxiliary diagnostic program for eye diseases using multimodal machine learning techniques and evaluate its diagnostic efficacy in real-world outpatient clinics.

NCT ID: NCT05896670 Active, not recruiting - Dry Eye Disease Clinical Trials

Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease

RELIEF
Start date: November 29, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to learn about licaminlimab (OCS-02) in the treatment of dry eye disease. The main question it aims to answer is if licaminlimab ophthalmic suspension is more effective than vehicle in treating signs of dry eye disease.

NCT ID: NCT05895500 Completed - Dry Eye Clinical Trials

Evaluate the Safety and Efficacy of Calcitonin Gene-Related Peptide (CGRP) Antagonists in Patients With Dry Eye Disease and Asthenopia

Start date: May 10, 2023
Phase:
Study type: Observational [Patient Registry]

Safety and Efficacy of Medications for Migraine in Patients with Dry Eye Disease or Asthenopia

NCT ID: NCT05888519 Completed - Dry Eye Disease Clinical Trials

Evaluation of Safety and Tolerability of Investigational Ocular Lubricants

Start date: July 24, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate investigational ocular lubricants for their safety and tolerability on subjects with mild to moderate dry eye disease.

NCT ID: NCT05876689 Recruiting - Glaucoma Clinical Trials

Swept Source OCT Imaging With the DREAM VG-OCT

Start date: October 9, 2023
Phase:
Study type: Observational

The Intalight Dream OCT is the first combo anterior plus posterior device to perform both OCT and OCT-A at depth of 16mm. This is especially useful in patient who are very nearsighted as it allows us to image all in one frame. The intention of this study is to see how the images differ on the same patients when compared to the Cirrus OCT and to test for the repeatability of the images on a single day.

NCT ID: NCT05865457 Not yet recruiting - Dry Eye Disease Clinical Trials

Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease

BUSTON-02
Start date: March 2024
Phase: N/A
Study type: Interventional

The goal of this interventional investigation is to compare BUFY02 with TRB02 in the treatment of patients with dry eye disease. The main questions it aims to answer are: - Is BUFY02 non-inferior to TRB02 in terms of signs of DED? - Is BUFY02 non-inferior to TRB02 in terms of symptoms of DED? Participants will be asked to: - Visit the trial site at 4 different timepoints - Use the allocated study treatment everyday until the end of the study (during 3 months) - Be examined by the investigator - Complete several questionnaires - Return unused study treatment. Researchers will compare BUFY02 to TRB02 to see if both study treatments provide similar effects on signs and symptoms of the disease, together with comparable safety.

NCT ID: NCT05865379 Not yet recruiting - Dry Eye Disease Clinical Trials

Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease

BUSTON-01
Start date: March 2024
Phase: N/A
Study type: Interventional

The goal of this interventional investigation is to compare BUFY01 with SVS20 in the treatment of patients with dry eye disease. The main questions it aims to answer are: - Is BUFY01 non-inferior to SVS20 in terms of signs of DED? - Is BUFY01 non-inferior to SVS20 in terms of symptoms of DED? Participants will be asked to: - Visit the trial site at 4 different timepoints - Use the allocated study treatment everyday until the end of the study (during 3 months) - Be examined by the investigator - Complete several questionnaires - Return unused study treatment. Researchers will compare BUFY01 to SVS20 to see if both study treatments provide similar effects on signs and symptoms of the disease, together with comparable safety.

NCT ID: NCT05857748 Withdrawn - Dry Eye Disease Clinical Trials

Examining the Clinical Characteristics, Treatment Patterns, Real-world Effectiveness, and Healthcare Resource Utilization of Patients With Dry Eye Disease

Start date: July 31, 2023
Phase:
Study type: Observational

A prospective, non- interventional, observational, non-comparative, longitudinal cohort study design will be used to address the objectives of this study using data collected through a healthcare.