Clinical Trials Logo
  1. Home
  2. Other
  3. NCT06275555

Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation

Extracorporeal Membrane Oxygenation Complication Clinical Trial

Official title:
Efficacy and Safety of Bivalirudin Versus Heparin in Anticoagulant Therapy of ECMO: a Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study was to evaluate the efficacy and safety of bivalirudin in anticoagulation therapy in patients with extracorporeal membrane oxygenation (ECMO) compared with unfractionated heparin.

Clinical Trial Description

Patients with ECMO who needed systemic anticoagulation were randomly divided into bivalirudin group and unfractionated heparin group;the efficacy of bivalirudin in ECMO anticoagulation was evaluated by comparing the percentage of time within the target anticoagulation level and the incidence of thrombotic complications between the two groups during ECMO; and the safety of bivalirudin in ECMO anticoagulation was evaluated by comparing bleeding complications, blood product infusion and the incidence of acute renal failure between the two groups. ;

Study Design

Related Conditions & MeSH terms

  • Extracorporeal Membrane Oxygenation Complication
Clinical Trial Details
NCT number NCT06275555
Study type Interventional
Source Beijing Anzhen Hospital
Contact Xiaotong Hou, MD
Phone 010-64456631
Email xt.hou@ccmu.edu.cn
Status Not yet recruiting
Phase N/A
Start date March 1, 2024
Completion date December 31, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05486559 - The ECMO-Free Trial N/A
Recruiting NCT04674657 - Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Not yet recruiting NCT05306392 - Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation N/A
Terminated NCT02280460 - ECMO: Optimization of Its Use
Completed NCT02271126 - TEG Anticoagulation Monitoring During ECMO Phase 1
Recruiting NCT05444764 - PREdiCtIon of Weanability, Survival and Functional outcomEs After ECLS
Completed NCT03659513 - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Not yet recruiting NCT06338345 - Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients N/A
Completed NCT05948332 - Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
Recruiting NCT04273607 - Anticoagulation-free VV ECMO for Acute Respiratory Failure Phase 2/Phase 3
Not yet recruiting NCT04956497 - Registry Study of Extracorporeal Cardiopulmonary Resuscitation (eCPR) in China
Completed NCT04052230 - Evolution of Diaphragm Thickness Under Veno-arterial ECMO
Completed NCT04620005 - Impact of Extra Corporal Membrane Oxygenation Services on Burnout Development in Intensive Care Units.
Terminated NCT04524585 - Partial Neuromuscular Blockade in Acute Respiratory Distress Syndrome N/A
Recruiting NCT05721105 - Evaluation of Long-term Quality of Life in Children Supported With ExtraCorporeal Membrane Oxygenation (ECMO)
Recruiting NCT06095518 - DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
Recruiting NCT03965208 - Safety and Efficacy of Bivalirudin Versus Heparin for Systemic Anticoagulation in Extracorporeal Membrane Oxygenation Phase 4
Not yet recruiting NCT05814094 - Red Blood Cell Transfusion in ECMO - A Feasibility Trial N/A
Not yet recruiting NCT06319677 - PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation Treatment
Completed NCT05338593 - Therapy and Outcome of Prolonged Veno-venous ECMO Therapy of Critically Ill ARDS Patients.