Extracorporeal Membrane Oxygenation Complication Clinical Trial
Official title:
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy, indicated in case of severe, possibly reversible pulmonary failure, refractory to conventional therapies. Despite advances, morbidity and mortality remain high. Severe neurological complications can occur during ECMO, but their exact etiology is not well understood. It is hypothesized that fast correction of severe hypercapnia, a common indication for venovenous ECMO, may be detrimental for the brain. The supposed mechanism is that fast correction of hypercapnia may result in massive cerebral vasoconstriction and impaired cerebral blood flow (CBF). In this prospective, observational study the aim is to quantify change in CBF during routine initial correction of severe hypercapnia during VV-ECMO. Furthermore, the investigators will record any other hemodynamic changes during VV-ECMO. The hypothesis is that a larger decline in PaCO2 will result in a larger decline of CBF.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05486559 -
The ECMO-Free Trial
|
N/A | |
Recruiting |
NCT04674657 -
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
|
||
Not yet recruiting |
NCT05306392 -
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
|
N/A | |
Terminated |
NCT02280460 -
ECMO: Optimization of Its Use
|
||
Completed |
NCT02271126 -
TEG Anticoagulation Monitoring During ECMO
|
Phase 1 | |
Recruiting |
NCT05444764 -
PREdiCtIon of Weanability, Survival and Functional outcomEs After ECLS
|
||
Completed |
NCT03659513 -
The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
|
||
Not yet recruiting |
NCT06338345 -
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
|
N/A | |
Completed |
NCT05948332 -
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
|
||
Recruiting |
NCT04273607 -
Anticoagulation-free VV ECMO for Acute Respiratory Failure
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT04956497 -
Registry Study of Extracorporeal Cardiopulmonary Resuscitation (eCPR) in China
|
||
Completed |
NCT04052230 -
Evolution of Diaphragm Thickness Under Veno-arterial ECMO
|
||
Completed |
NCT04620005 -
Impact of Extra Corporal Membrane Oxygenation Services on Burnout Development in Intensive Care Units.
|
||
Terminated |
NCT04524585 -
Partial Neuromuscular Blockade in Acute Respiratory Distress Syndrome
|
N/A | |
Recruiting |
NCT05721105 -
Evaluation of Long-term Quality of Life in Children Supported With ExtraCorporeal Membrane Oxygenation (ECMO)
|
||
Recruiting |
NCT06095518 -
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
|
||
Recruiting |
NCT03965208 -
Safety and Efficacy of Bivalirudin Versus Heparin for Systemic Anticoagulation in Extracorporeal Membrane Oxygenation
|
Phase 4 | |
Not yet recruiting |
NCT05814094 -
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
|
N/A | |
Not yet recruiting |
NCT06319677 -
PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation Treatment
|
||
Completed |
NCT05338593 -
Therapy and Outcome of Prolonged Veno-venous ECMO Therapy of Critically Ill ARDS Patients.
|