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Clinical Trial Summary

This phase II trial compares the effect of adding radiation therapy to the usual maintenance therapy with Serplulimab versus Serplulimab alone in patients who have already received Serplulimab plus chemotherapy for the treatment of extensive stage small cell lung cancer .


Clinical Trial Description

This phase II trial compares the effect of adding radiation therapy to the usual maintenance therapy with Serplulimab versus Serplulimab alone in patients who have already received Serplulimab plus chemotherapy for the treatment of extensive stage small cell lung cancer . Immunotherapy with monoclonal antibodies, such as Serplulimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving radiation therapy in addition to Serplulimab may extend the time without extensive small cell lung cancer growing or spreading compared to Serplulimab alone. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06350162
Study type Interventional
Source Zhejiang Cancer Hospital
Contact Yun Fan, PHD
Phone 0571-88122092
Email fanyun@zjcc.org.cn
Status Recruiting
Phase Phase 2
Start date October 18, 2023
Completion date December 31, 2025