Exposure Clinical Trial
Official title:
The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling Agents (R01)
This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.
PRIMARY OBJECTIVES: I. Assess the abuse liability of e-liquids with and without the presence of synthetic cooling agents. II. Determine the impact of synthetic cooling agents and flavor on EC puffing behavior (topography). III. Determine the exposure ranges (harmful and potentially harmful constituents [HPHCs], other toxicants) from vaping e-liquids with and without the presence of synthetic cooling agents. OUTLINE: Participants attend 4 sessions where they receive 1 of 4 randomly assigned flavored e-cigarettes. Participants use the e cigarettes for vaping followed by ad libitum vaping. Participants also complete surveys and undergo biosample collection throughout the study. ;
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