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Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

Low Back Pain Clinical Trial

Official title:
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

Clinical Trial Summary

This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.

Clinical Trial Description

Investigators will pursue this goal in both experimental and clinical models at two sites (Florida State U/FSU & Mass General Hospital/MGH), implementing parallel enrollment of large and diverse samples (140 healthy participants and 60 patients with chronic low back pain/cLBP). Leveraging the fully developed multimodal neuroimaging methodology-simultaneous EEG-fMRI and combined EEG-MEG-fMRI, the investigators will investigate TC dysconnectivity (fMRI) and alpha dysrhythmia (EEG/MEG) during experimental pressure pain and chronic back pain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05763758
Study type Observational
Source Massachusetts General Hospital
Contact Jian Kong
Phone 16179620978
Email jkong2@mgh.harvard.edu
Status Not yet recruiting
Phase
Start date May 1, 2023
Completion date December 31, 2024
View Details
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