The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

Exercise Clinical Trial

Official title:

The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05468255
• Other study ID #: AGEGLYFMD
• Status: Recruiting
• Phase: N/A
• Start date: July 25, 2022
• Est. completion date: April 1, 2025

Study information

• Verified date: April 2024
• Source: Old Dominion University
• Contact: Leryn Reynolds
• Phone: 757-683-4974
• Email: lreynold[@]odu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: April 1, 2025
• Est. primary completion date: January 30, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. 55 years and older, 18-40 years old

2. Healthy, physically active, performing at least 90 min/week of physical activity

3. Free of physical limitations that may interfere with alterations in daily physical activity levels

Exclusion Criteria:

1. Physician diagnosed HIV, hepatitis, or tuberculosis.

2. Body weight change of greater than 5% within the previous 2 months

3. Smoking within the previous 2 months.

4. Taking medications that alter blood glucose levels

Related Conditions & MeSH terms

• Exercise
• Glucose Intolerance
• Vascular Function

Intervention

Other:
• removal of exercise
Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.

Locations

Country	Name	City	State
United States	Old Dominion University	Norfolk	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
Old Dominion University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Continuous glucose monitoring		3 days before removal of exercise
Primary	Continuous glucose monitoring		After removal of exercise for 5 days
Primary	Continuous glucose monitoring		After return to exercise for 3 days
Primary	Flow mediated dilation	This measure assess blood vessel health non-invasively	3 days before removal of exercise
Primary	Flow mediated dilation (vascular health)	This measure assess blood vessel health non-invasively	After removal of exercise for 5 days
Primary	Flow mediated dilation (vascular health)	This measure assess blood vessel health non-invasively	After return to exercise for 3 days